Korean J Lab Med.
2005 Jun;25(3):152-154.
Double Minutes Containing C-MYC oncogene with a Normal Karyotype in Acute Myelogenous Leukemia: A Case Report
- Affiliations
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- 1Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
- 2Department of Laboratory Medicine, Inha University College of Medicine, Incheon, Korea. moonys@inha.ac.kr
- 3Department of Laboratory Medicine, Sungkyunkwan Univerity School of Medicine, Samsung Medical Center, Seoul, Korea.
Abstract
- We report a case of a female karyotype that was normal except for double minutes (dmin) in acute myeloid leukemia. Using fluorescence in situ hybridization, the amplification of C-MYC was detected in both interphase and metaphase cells. The patient of the present case had received only limited therapy with cytosine arabinoside, but lived for more than one year. It supports the recent notion that dmin may not necessarily be associated with a poor outcome.
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