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Pulmonary Artery Intimal Sarcoma versus Pulmonary Artery Thromboembolism: CT and Clinical Findings

Kim C, Kim MY, Kang JW, Song JS, Lee KY, Kim SS

OBJECTIVE: To describe CT and clinical findings of pulmonary artery intimal sarcoma (PAIS) compared with those of pulmonary thromboembolism (PTE), to investigate MRI and positron emission tomography (PET)-CT findings of...
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Anaplastic Large Cell Lymphoma with Massive Eosinophilia and Complex Karyotype Initially Misdiagnosed as Chronic Eosinophilic Leukemia

So MK, Park S, Cho MS, Mun YC, Huh J

We report a patient with massive eosinophilia and a complex karyotype that was initially misdiagnosed as chronic eosinophilic leukemia (CEL), but later diagnosed as anaplastic large cell lymphoma (ALCL) masked...
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Clinicopathological Characteristics of Hyperdiploidy with High-Risk Cytogenetics in Multiple Myeloma

Yang N, Mun YC, Seong CM, Huh HJ, Huh J

In multiple myeloma (MM), hyperdiploidy (HD) is known to impart longer overall survival. However, it is unclear whether coexistent HD ameliorates the adverse effects of known high-risk cytogenetics in MM...
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Dysregulation of Telomere Lengths and Telomerase Activity in Myelodysplastic Syndrome

Park HS, Choi J, See CJ, Kim JA, Park SN, Im K, Kim SM, Lee DS, Hwang SM

BACKGROUND: Telomere shortening is thought to be involved in the pathophysiology of myeloid malignancies, but telomere lengths (TL) during interphase and metaphase in hematopoietic malignancies have not been analyzed. We...
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Cryptic Insertion of the BCR Gene at 9q34 in Philadelphia-Negative Chronic Myelogenous Leukaemia

Kim HJ, Ji M, Kim H, Moon HW, Hur M, Yun YM

Chronic myelogenous leukaemia (CML) is a myeloproliferative neoplasm that is almost always characterised by the presence of t(9;22)(q34;q11.2). Approximately 5% to 10% of CML patients lack cytogenetic evidence of t(9;22)(q34;q11.2)...
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Prenatal diagnosis of a 7q21.13q22.1 deletion detected using high-resolution microarray

Kim KB, Ha JS, Shin SJ, Kim CS, Bae JG

We report a case of de novo 7q interstitial deletion detected by conventional karyotyping and by microarray of amniotic fluid sampled during the prenatal period. A 32-year-old pregnant woman was...
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Magnetic Resonance Imaging Features of Neuromyelitis Optica

You SK, Song CJ, Park WJ, Lee IH, Son EH

  • KMID: 2322593
  • J Korean Soc Radiol.
  • 2013 May;68(5):375-383.
PURPOSE: To report the magnetic resonance (MR) imaging features of the spinal cord and brain in patients of neuromyelitis optica (NMO). MATERIALS AND METHODS: Between January 2001 and March 2010, the...
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Prognostic significance of syndecan-1 expression in cervical cancers

Kim YI, Lee A, Lee BH, Kim SY

OBJECTIVE: Syndecans are reported to have variable expression in several solid tumors and blood cancers. The cause provoking altered expression of syndecans is not known to date. We studied copy...
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Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH

Kim MK, Mun YC, Seong CM, Chung WS, Huh J

A variant Philadelphia chromosome (Ph) is generated from translocation of one or more partner chromosomes in addition to chromosomes 9 and 22. We have described the cases of 2 patients...
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p16 Deletion Fluorescence in situ Hybridization in Childhood Acute Lymphoblastic Leukemia

Park EK, Kang SJ, Kim SY, Kang JW, Lim YJ, Lee YH, Lee CH

  • KMID: 2168948
  • Clin Pediatr Hematol Oncol.
  • 2010 Oct;17(2):196-203.
PURPOSE: Cytogenetic abnormalities are one of the most reliable prognostic factors in acute leukemia. This study estimated the incidence of the p16 deletion to demonstrate the usefulness of interphase fluorescence...
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Clinical utility of FISH analysis in addition to G-banded karyotype in hematologic malignancies and proposal of a practical approach

Kwon WK, Lee JY, Mun YC, Seong CM, Chung WS, Huh J

BACKGROUND: Fluorescence in situ hybridization (FISH) analysis can provide important information in the management of patients with hematologic malignancies. However, FISH performed in addition to G-banded karyotype can be labor-intensive...
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Prenatal Diagnosis of the 22q11.2 Duplication Syndrome

Lee MH, Park SY, Lee BY, Choi EY, Kim JW, Park JY, Lee YW, Oh AR, Lee SY, Yang JH, Ryu HM

  • KMID: 1473823
  • J Genet Med.
  • 2009 Dec;6(2):175-178.
The 22q11.2 duplication syndrome is an extremely variable disorder with a phenotype ranging from normal to congenital defects and learning disabilities. Recently, the detection rate of 22q11.2 duplication has been...
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Comparison between Conventional Cytogenetics and Interphase Fluorescence in situ Hybridization (FISH) for Patients with Multiple Myeloma

Kim SH, Kim JH, Lee DM, Lee S, Oh SY, Kwon HC, Kim KE, Han JY, Kim HJ

BACKGROUND: For patients with multiple myeloma (MM), different strategies are used to detect chromosomal abnormalities (CA). There have been a few studies that have directly compared FISH with conventional cytogenetics...
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A Case of Atypical CML with Micro BCR/ABL Rearrangement

Kim JH, Lee WM, Ryoo NH, Ha JS, Jeon DS, Kim JR, Kwon KY

Microtype BCR/ABL rearrangement is extremely rare and has been known to be associated with neutrophilic chronic myeloid leukemia (N-CML). However, there is more to be understood regarding this phenotype. We...
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Pseudoisodicentric X chromosome in a female with primary amenorrhea

Park SH, Shim SH, Chin MU, Kang SJ, Bae SM, Sohn SM, Cha DH, Yoon TK, Cho JH

  • KMID: 2184449
  • J Genet Med.
  • 2008 Jun;5(1):61-64.
A 24-year-old female with primary amenorrhea was referred for a chromosome study. The karyotype of the patient was 46,X,der(X) under initial GTG-banding analysis. Fluorescence in situ hybridization (FISH) analysis with...
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Rapid prenatal diagnosis of chromosome aneuploidies in 943 uncultured amniotic fluid samples by fluorescence in situ hybridization (FISH)

Han SH, Kang JS, An JW, Lee A, Yang YH, Lee KP, Lee KR

  • KMID: 2184447
  • J Genet Med.
  • 2008 Jun;5(1):47-54.
PURPOSE: Fluorescence in situ hybridization (FISH) on uncultured amniotic fluid cells offers the opportunity for rapid screening of aneuploidies and has become an integral part of the current practice in...
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Electrical Stimulation Parameters in Normal andDegenerate Rabbit Retina

Jin GH, Goo YS

  • KMID: 1482454
  • Korean J Med Phys.
  • 2008 Mar;19(1):73-79.
Retinal prosthesis is regarded as the most feasible method for the blind caused by retinal diseases such as retinitis pigmentosa (RP) or age related macular degeneration (AMD). Recently Korean consortium...
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Rapid detection of aneuploidy using FISH in uncultured amniocytes for prenatal diagnosis : 8-year experience

Hwang D, Lee DS, Choe J, Choi HS, Min J, Lee S, Kim KC

  • KMID: 2288522
  • J Genet Med.
  • 2007 Dec;4(2):190-195.
PURPOSE: FISH is suggested as a useful tool for rapid detection of specific aneuploidy in uncultured amniocytes abnormality in interphase nucleus. In this study, we are going to share our...
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Double Minutes Containing C-MYC oncogene with a Normal Karyotype in Acute Myelogenous Leukemia: A Case Report

Kim HS, Cho HC, Moon Y, Nahm CH, Choi JW, Yi SG, Kim SH

  • KMID: 2082793
  • Korean J Lab Med.
  • 2005 Jun;25(3):152-154.
We report a case of a female karyotype that was normal except for double minutes (dmin) in acute myeloid leukemia. Using fluorescence in situ hybridization, the amplification of C-MYC was...
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Molecular Cytogenetic Analysis of Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia

Woo HY, Kim DW, Park H, Seong KW, Koo HH, Kim SH

The aims of this study were to estimate the incidences of BCR/ABL, MLL, TEL/AML1 rearrangements, and p16 deletions in childhood acute lymphoblastic leukemia (ALL), to identify new abnormalities, and to...
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