Korean J Clin Pathol.
2000 Aug;20(4):364-366.
A Case of Acute Myelogenous Leukemia with a 47,XYY Karyotype
- Affiliations
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- 1Depatment of Clinical Pathology, College of Medicine, Kosin University, Pusan, Korea.
- 2Department of Internal Medicine, College of Medicine, Kosin University, Pusan, Korea.
Abstract
- A 61 year-old male patient admitted with the complaint of chest pain. During the evaluation, immature cells were found on the peripheral blood smear. Bone marrow aspiration and biopsy were performed. Diagnosis of acute myelogenous leukemia(FAB classification, M2) was made. In the chromosome study using peripheral blood and bone marrow, 47,XYY karyotype was established. Acute myelogenous leukemia has rarely been diagnosed in patients with 47,XYY karyotype, and the effect of extra Y chromosome on oncogenesis is not clear. More studies are needed to be done to clear up the relation between XYY karyptype and leukemia.
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