Korean J Obstet Gynecol.  2005 Feb;48(2):462-466.

47,XYY male with increased nuchal fold thickness, choroid plexus cyst and limb anomaly: A case report

• Kim SH
• Kim SG
• Kim TY
• Jeong SY
• Choi TY
• Jeong OS
• Moon HS

Abstract

47,XYY males are found in approximately 1 per 1,000 men. There is no significant difference in intelligence compared with a normal karyotype group. 47,XYY males are fertile and are considered to be relatively tall in stature owing to the increased growth velocity during the earliest childhood. It has been known that 47,XYY males are usually quite normally developed at birth with normal birth weight and length without any physical abnormalities. We have experienced a case of 47,XYY male with increased nuchal fold thickness, choroid plexus cyst and limb anomaly and we report the case with brief review of the literature. A 31-year-old woman, who had terminated her first pregnancy due to limb anomaly at 24 weeks gestation, received ultrasonography at about 16 weeks gestation and was found having a fetus with increased nuchal fold, choroid plexus cyst and limb anomaly. Through the genetic counselling, her pregnancy was terminated and the chromosome karyotyping was performed with the fetal tissue and parent's peripheral blood. The results revealed that the parents had normal karyotypes, but the karyotype of the fetus showed 47,XYY.

Keyword

47,XYY; Limb anomaly; Choroid plexus cyst; Increased nuchal fold thickness

MeSH Terms

Adult
Birth Weight
Choroid Plexus*
Choroid*
Extremities*
Female
Fetus
Humans
Intelligence
Karyotype
Karyotyping
Male*
Nuchal Translucency Measurement*
Parents
Parturition
Pregnancy
Ultrasonography