Korean J Obstet Gynecol.  2007 Oct;50(10):1336-1343.

The significance of maternal serum and umbilical cord blood leptin concentration with intrauterine fetal growth restriction and/or preeclampsia

• Lee GS
• Kil KC
• Lee Y
• Ahn HY
• Hur SY
• Shin EY
• Shin JC
• Lew YO

Abstract

OBJECTIVE
To ascertain whether fetal growth restriction with or without preeclampsia is associated with alteration of leptin concentration in maternal and umbilical cord serum.
METHODS
Maternal serum and umbilical cord blood leptin concentrations were determined by ELISA assay in 25 women with singletone pregnancies complicated by fetal growth restriction without preeclampsia (IUGR), in 11 women with singletone pregnancies complicated by fetal growth restriction with preeclampsia (IUGR+PE), in 9 women with singletone pregnancies complicated by preeclampsia without fetal growth restriction (PE), and in 13 women with uncomplicated singletone pregnancies (Control).
RESULTS
Maternal weight and BMI before pregnancy and in delivery were significantly different among groups. The lowest weight and BMI before pregnancy and in delivery was group IUGR. Neonatal birth weight was significantly different among groups. The lowest birth weight was group IUGR+PE. Maternal serum leptin concentration and umbilical cord leptin concentration were not significantly different among groups. Maternal serum leptin levels were not significantly correlated with maternal BMI or with neonatal birth weight. Umbilical cord blood leptin levels were significantly correlated with neonatal birth weight.
CONCLUSION
Maternal serum leptin concentration and umbilical cord blood leptin levels were independent of presence of preeclampsia and/or IUGR. Umbilical cord blood leptin reflects neonatal birth weight.

Keyword

Leptin; Intrauterine growth restriction; Preeclampsia

MeSH Terms

Birth Weight
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood*
Fetal Development*
Fetal Growth Retardation
Humans
Leptin
Pre-Eclampsia*
Pregnancy
Umbilical Cord*
Leptin