Korean J Pediatr.  2010 Apr;53(4):554-559. 10.3345/kjp.2010.53.4.554.

A study on the therapeutic effects of Topiramate according to the types of migraine

Affiliations
  • 1Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Korea. pedikyung@yahoo.co.kr

Abstract

PURPOSE
The purpose of this study was to evaluate whether the therapeutic effects of topiramate differ according to the types of migraine.
METHODS
We recruited 38 children and adolescents with migraine who had been treated with topiramate. The effect of topiramate was evaluated on the basis of the change in the frequency of migraine attacks after treatment.
RESULTS
Among patients having migraine with aura, 85.7% showed complete recovery, 1 (7.1%) showed partial recovery, and 1 did not show any recovery. Among patients having migraine without aura, 47.1% showed complete recovery, 29.4 % showed partial recovery, and 23.5% showed no recovery. Among patients suspected with migraine, 1 (20%) showed complete recovery, 1 (20%) showed partial recovery, and 3 (60%) showed no recovery.
CONCLUSION
Our results indicated that topiramate exhibited excellent therapeutic effects for migraine accompanied with aura, and it was effective in migraine without aura. However, the effect of topiramate in patients suspected with migraine was uncertain.

Keyword

Migraine; Aura; Topiramate; Child

MeSH Terms

Adolescent
Child
Epilepsy
Fructose
Humans
Migraine Disorders
Migraine with Aura
Migraine without Aura
Fructose
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