J Korean Child Neurol Soc.  2007 May;15(1):58-66.

The Study for Therapeutic Effects of Topiramate on Pediatric Patients with Migraine, Especially Accompanied by Aura

• Kim HS
• Whang SJ
• Lee JW
• Kim TH
• Lee JS
• Cho KL

Abstract

PURPOSE: This study was undertaken to investigate the therapeutic effects of topiramate on pediatric patients with migraine, especially migraine accompanied by aura.
METHODS
From January. 2004 to December. 2006, we reviewed the medical records of 27 patients who were diagnosed as migraine and treated with topiramate. And we analysed to see whether there was any improvement of symptoms based on the migraine criteria by International Headache Society.
RESULTS
There was a correlation between the migraine criteria and the improvement of symptoms after the treatment by topiramate. The symptoms of nausea, vomiting and hypersensitivity to light and sound were not associated with the improvement of symptoms after the treatment by topiramate. The symptom of aura was related with the improvement of symptoms, moreover, closely related with disappearance of symptoms after the treatment by topiramate.
CONCLUSION
It is estimated that more accurate diagnosis coupled with the presence of aura is a condition to improve the treatment effects of topiramate.

Keyword

Migraine criteria; Topiramate

MeSH Terms

Diagnosis
Epilepsy*
Headache
Humans
Hypersensitivity
Medical Records
Migraine Disorders*
Nausea
Vomiting