Korean J Urol.  2005 Apr;46(4):420-421.

Chronic Cyclophosphamide Induced Cystitis that is Improved by Mesna

• Woo W
• Lee C
• Kim S
• Kwon O
• Ahn S
• Seong B

Abstract

Cyclophosphamide is alkylating agent used in the treatment of various solid tumors. Mucosal irritation by acrolein, the metabolite of cyclophosphamide, is believed to cause various symptoms of cystitis. The thiol compound, sodium 2-mercaptoethane sulfonate (Mesna), has been found to inactivate acrolein. We present an unusual case of a 64-year-old woman, who was treated as chronic cystitis. Her symptoms did not improve, so she was treated with Mesna under the assumption of cyclophosphamide induced cystitis; her symptoms then improved.

Keyword

Mesna; Cyclophosphamide; Cystitis

MeSH Terms

Acrolein
Cyclophosphamide*
Cystitis*
Female
Humans
Mesna*
Middle Aged
Sodium
Acrolein
Cyclophosphamide
Mesna
Sodium