Cell proliferation of transitional cell carcinoma of the bladder measured bu monoclonal antibody Ki-67

Lee, Jong Bouk; Lee, Sang Eun

Abstract

The cell proliferation of 29 human transitional cell carcinomas of the bladder was assessed immunohistochemically using the monoclonal antibody Ki-67. Normal mucosa had a mean value of 0.67+/-0.20% cells positive for Ki-67, whereas the average of grade 1. 2, 3 was 5.2+/-1.8%. 12.2: 5.0%, 18.0+/-4.6%. respectively. Significant differences were noted between grade 1 and grade 2 (p intermediate Nde (grade 2) showed wide range of Ki-67 labeling index (from 6.5 to 23.5%) compared with ether grades. The labeling indices of Ki-67 were 5.5+/-2.1% for stage Ta. 11.9+/-4.2% for T1 and 17.4+/-5.8% for stages equal to or higher than T2. Significant difference was noted between stage Ta and T1 (p<0.001 ), suggesting that tumor invasion to lamina propria is a important indicator of cell proliferation. Significant difference was also noted between stage T1 and T2 or higher (p<0.01). In recurrent tumors, Ki-67 indices did not show significant difference between the tumors with short recurrent intervals(men duration of recurrence <6 months) and long(>6 months). In conclusion. we suggest that Ki-67 may be a useful monoclonal antibody for easy evaluation of proliferating cells in transitional cell carcinomas of the bladder and Ki-67 labeling indices may serves as a additional prognostic factor to the current histologic grade of the bladder tumor, especially in the tumors with the intermediate grade.