Korean J Urol.  1993 Apr;34(2):225-231.

Identification of infiltrating T-lymphocytes and human NK cells in bladder cancer tissue using monoclonal antibodies and the immunoperoxidase technique

Affiliations
  • 1Department of Urology, Seoul City Dong Bu Hospital, Seoul, Korea.
  • 2Department of Urology, Korea University, College of Medicine, Seoul, Korea.

Abstract

A study was performed using monoclonal antibodies and the immunoperoxidase technique to identify infiltration of T lymphocytes and NK cells in 25 patients with transitional cell carcinoma of the bladder. The density and distribution of infiltrating T lymphocytes were evaluated used the monoclonal antibody UCHL1 and the monoclonal antibody anti-Leu-7 (HNK-1) was used to identify human NK cells. The results were as follows: 1. There was a significant positive correlation between the intensity of T cell infiltration and the number of NK cells (p=0.001). 2. There was a significant positive correlation between the intensity of T cell infiltration and the grade (p=0.006). 3. There was a significant positive correlation between the number of NK cells and the grade (p=0.024). 4. T cells were tended to contact with cancer cells, accumulated in the necrotic tissue and infiltrated in the submucosa. 5. NK cells were identified in the venules of noncancerous bladder tissue in contrast to the stroma of cancer tissue. These findings suggest the importance or T and NK cells in regulation of the regional immune responses in transitional cell carcinoma of the bladder.

Keyword

Transitional cell carcinoma; Bladder; Regional immune response; T cell; NK cell

MeSH Terms

Antibodies, Monoclonal*
Carcinoma, Transitional Cell
Humans*
Immunoenzyme Techniques*
Killer Cells, Natural*
T-Lymphocytes*
Urinary Bladder Neoplasms*
Urinary Bladder*
Venules
Antibodies, Monoclonal
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