Korean J Dermatol.  1984 Dec;22(6):588-592.

T Cells in Cutaneous Lesions of Erythema Multiforme

• Lee CW
• Whang KU
• Kim JH

Abstract

Anti-T cell monoclonal antibodies(OKT series. OKT4a, OKTSA, OKT)1) immunoperoxidase technique study for the presence of T cells in cutaneous lesions from four patients with erythema multiforme showed that most dermal and epidermal lymphoid cells were reactive with monoclonal antibodies to anti-pan T cell (l3KT11) in this semiquantitative assay. In the dermis most of the perivascular lirmphoid infiltrates were reactive with anti-helper/inducer T cell antibody, but in the epidermis and in the derrnopidermal interface the predominant cells were identified as suppressor/cytotoxic T cells. The histologic and immunopathologic changes in erythema multiforme appear to be due in part to cellular immune rnechanisms with the lyrnphocyte as the predominant effector cell. But complex interplays with other humoral immune mechanisms might be in work for the development of erythema multiforme.

MeSH Terms

Antibodies, Monoclonal
Dermis
Epidermis
Erythema Multiforme*
Erythema*
Humans
Immunoenzyme Techniques
Lymphocytes
T-Lymphocytes*
Antibodies, Monoclonal