J Korean Child Neurol Soc.  2012 Sep;20(3):196-200.

Detection of Human Herpesvirus-6 (HHV-6) in Cerebrospinal Fluid of a Patient with Fatal Status Epilepticus

Affiliations
  • 1Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea. smchoped@hotmail.com

Abstract

Human herpesvirus-6 (HHV-6) often causes mild illnesses, but is rarely associated with encephalitis or other fatal neurological conditions. We report a girl who died of a intractable status epilepticus from HHV-6. A 14-month-old girl presented with focal motor seizures in right extremities evolving to generalized convulsive status epilepticus. She had a history of mild diarrhea for 4 days and high fever for 2 days. Although she was treated with lorazepam, phenytoin, phenobarbital, and continuous midazolam infusion, generalized seizures continued for 3 hours after arrival. She became seizure free, but remained unconscious and ended up to death at the 44 days of hospitalization. The CSF HHV-6 DNA PCR turned out to be positive.

Keyword

Human herpesvirus-6; Encephalitis; Status epilepticus; Brain death

MeSH Terms

Brain Death
Diarrhea
DNA
Encephalitis
Extremities
Fever
Herpesvirus 6, Human
Hospitalization
Humans
Infant
Lorazepam
Midazolam
Phenobarbital
Phenytoin
Polymerase Chain Reaction
Seizures
Status Epilepticus
Unconscious (Psychology)
DNA
Lorazepam
Midazolam
Phenobarbital
Phenytoin
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