Clin Pediatr Hematol Oncol.
2010 Apr;17(1):43-50.
Clinical Significance of Helical Tomotherapy in Children with Extracranial Disease
- Affiliations
-
- 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. dcjeong@catholic.ac.kr
- 2Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 3Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- PURPOSE
Radiation therapy (RT) is one of the most important treatment options in pediatric oncology. Conventional RT is effective in short term tumor control, but may cause normal tissue or organ damage, acute toxicities or late toxicities. Helical tomotherapy as an image-guided IMRT (intensity-modulated RT) can provide homogeneous dose distribution within the target region by conformal images. We evaluated the effect of tomotherapy and acute toxicities during tomotherapy in children with extracranial tumors.
METHODS
We retrospectively reviewed medical records of children who received tomotherapy between January, 2007 and August, 2009 in Incheon St. Mary's hospital, The Catholic University of Korea. We investigated patients' diagnosis and disease status, objectives of tomotherapy, radiation dose and field, organ at risk, and survival.
RESULTS
Seven children with extracranial malignancies experienced nine tomotherapies. One of them received tomotherapy for curative treatment, the others for palliation with disease control. Three children died due to disease progression after tomotherapy. Two children experienced grade II leukopenia with thrombocytopenia, and one boy experienced transient grade II xerostomia with controlled permanent hypothyroidism.
CONCLUSION
elical tomotherapy is a very effective treatment modality in the pediatric field without causing serious acute toxicities. Helical tomotherapy can be applied to a complicated anatomical site, recurrent tumor site, multiple metastasis, while sparing normal organs or tissues. Further prospective clinical trials and close follow-up will be needed to prove the long-term effects of helical tomotherapy.
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