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Oncologic Outcomes of T1–T2N0 Glottic Cancer Treatment: Single Center Experiences of 417 Patients Over 20 Years

Choi SY, Chung MK, Ahn YC, Oh D, Son YI

Background and Objectives For T1–T2 early glottic cancer, single modality treatment with radiation therapy (RT) or transoral laser microsurgery is the standard therapeutic option. However, the choice between surgery and...
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Nuclear Factor Erythroid 2-Related Factor 2/Kelch-Like ECH-Associated Protein 1 as a Predictor of Prognosis and Radiotherapy Resistance in Patients With Locally Advanced Rectal Cancer: A Prospective Analysis

Park JM, Kim S, Bae SU, Byun SJ, Seo I, Lee HW

Background: The nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathway is involved in the regulation of cellular responses to oxidative stress. Nrf2 acts as a cell...
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Radiotherapy for Diffuse Intrinsic Pontine Glioma: Insufficient but Indispensable

Kim HJ, Suh CO

Diffuse intrinsic pontine gliomas (DIPGs) account for 10%–20% of all central nervous system tumors in children and are the leading cause of death in children with brain tumors. Although many...
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Impact of Postmastectomy Radiation Therapy on Breast Cancer Patients According to Pathologic Nodal Status after Modern Neoadjuvant Chemotherapy

Kim D, Kim JH, Kim IA, Chang JH, Shin KH

Purpose The utility of postmastectomy radiation therapy (PMRT) for breast cancer patients after neoadjuvant chemotherapy (NAC) is highly controversial. This study evaluated the impact of PMRT according to pathologic nodal...
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Clinical Outcomes of Moderately Hypofractionated Concurrent Chemoradiotherapy for Newly Diagnosed Glioblastoma

Kim N, Lim DH, Choi JW, Lee JI, Kong DS, Seol HJ, Nam DH

Purpose: Hypofractionated radiotherapy (HypoRT) has recently been implemented in patients with glioblastoma (GBM) receiving concurrent temozolomide. Lymphopenia during treatment (LDT) is considered an important prognostic factor of clinical outcomes for...
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Top Ten Lessons Learned from Trials in Oligometastatic Cancers

Tan VS, Palma DA

Recent evidence supports the role of aggressive local treatment in the oligometastatic setting. In this review, we discuss the top 10 lessons we have learned from trials in oligometastatic cancers....
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Image Guided Radiation Therapy

Hwang UJ, Min BJ, Kim M, Kim KH

Over the past decades, radiation therapy combined with imaging modalities that ensure optimal image guidance has revolutionized cancer treatment. The two major purposes of using imaging modalities in radiotherapy are...
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Journey to hypofractionation in radiotherapy for breast cancer: critical reviews for recent updates

Kim N, Kim YB

Historical conventional fractionated radiation therapy (RT) for breast cancer consisted of 1.8–2.0 Gy per fraction with a total dose of 45–60 Gy over 5–7 weeks. Based on radiobiological characteristics, a...
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Radiation Therapy for Recurrent or Residual Pituitary Macroadenoma Invading Extrasellar Structures

Kim K, Cho J, Moon JH, Kim EH, Yoon HI

Purpose: This study aimed to evaluate the efficacy of radiation therapy (RT) for recurrent or residual pituitary macroadenoma (PMA) invading extrasellar regions. Materials and Methods: Patients from 2000 to 2020 who...
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Comparison of Dose Statistics of IntensityModulated Radiation Therapy Plan from Varian Eclipse Treatment Planning System with Novel Python-Based Indigenously Developed Software

Dashnamoorthy S, Rajamanickam K, Jeyasingh E, Pandey VP, Nachimuthu K, Ahmed I, Venkatraman P

Purpose: Planning for radiotherapy relies on implicit estimation of the probability of tumor control and the probability of complications in adjacent normal tissues for a given dose distribution. Methods: The aim...
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Radiofrequency Ablation versus Stereotactic Body Radiation Therapy in the Treatment of Colorectal Cancer Liver Metastases

Yu J, Kim DH, Lee J, Shin YM, Kim JH, Yoon SM, Jung J, Kim JC, Yu CS, Lim SB, Park IJ, Kim TW, Hong YS, Kim SY, Kim JE, Park Jh, Kim SY

Purpose This study aimed to compare the treatment outcomes of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT) for colorectal cancer liver metastases (CRLM) and to determine the favorable treatment...
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Genetic variations affecting response of radiotherapy

Choi EK

Radiation therapy (RT) is a very important treatment for cancer that irradiates a large amount of radiation to lead cancer cells and tissues to death. The progression of RT in...
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An overview of radiation-induced heart disease

Ellahham S, Khalouf A, Elkhazendar M, Dababo N, Manla Y

Radiation therapy (RT) has dramatically improved cancer survival, leading to several inevitable complications. Unintentional irradiation of the heart can lead to radiation-induced heart disease (RIHD), including cardiomyopathy, pericarditis, coronary artery...
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Craniospinal irradiation for respiratory failure secondary to central nervous system Erdheim-Chester disease

Prasad RN, Kobalka PJ, Perlow HK, Prevedello DM, Blakaj DM, Raval RR, Palmer JD

Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis typically featuring lower extremity osteosclerosis (96%) from Langerin-negative histiocytes with fibrosis. Central nervous system (CNS)-only disease is extremely rare, and particularly...
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Post-radiation neutrophil-to-lymphocyte ratio is a prognostic marker in patients with localized pancreatic adenocarcinoma treated with anti-PD-1 antibody and stereotactic body radiation therapy

Reddy AV, Hill CS, Sehgal S, Zheng L, He J, Laheru DA, Jesus-Acosta AD, Herman JM, Meyer J, Narang AK

Purpose: To investigate the role of pre- and post-stereotactic body radiation therapy (SBRT) neutrophil-to-lymphocyte ratio (NLR) in patients with localized pancreatic cancer treated with anti-PD-1 (programmed cell death protein-1) antibody...
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Recent Updates on Radiation Therapy for Pediatric Optic Pathway Glioma

Kim N, Lim DH

Optic pathway glioma (OPG) is a rare tumor located in optic nerve, optic tract, or optic chiasm. Treatment options for OPG include surgery, radiation therapy (RT), and chemotherapy. Although RT...
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Radiation Response Prediction Model Based on Integrated Clinical and Genomic Data Analysis

Jang BS, Chang JH, Jeon SH, Song MG, Lee KH, Im SA, Kim JI, Kim TY, Chie EK

Purpose The value of the genomic profiling by targeted gene-sequencing on radiation therapy response prediction was evaluated through integrated analysis including clinical information. Radiation response prediction model was constructed based on...
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PA1 cells containing a truncated DNA polymerase β protein are more sensitive to gamma radiation

Patra A, Nag A, Chakraborty A, Bhattacharyya N

Purpose: DNA polymerase β (Polβ) acts in the base excision repair (BER) pathway. Mutations in DNA polymerase β (Polβ) are associated with different cancers. A variant of Polβ with a...
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Anaplastic Thyroid Cancer Successfully Treated With Paclitaxel and Radiation: A Case Report

Yun HJ, Kim SM, Chang HJ, Lee YS, Chang HS

Anaplastic thyroid cancer (ATC) is rare and aggressive, with an extremely low cure rate and poor prognosis. Here, we report a case of treating patients with ATC through multimodal treatment...
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Reviewing the potential role of radiation therapy in gallbladder cancer: an update

Kumar D, Kiran NM, Khosla D

Gallbladder cancer is a highly malignant disease with a poor prognosis. It is the most common cancer of the biliary tract pathway. Although surgery remains the treatment of choice for...
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