J Korean Acad Prosthodont.  2013 Apr;51(2):82-89. 10.4047/jkap.2013.51.2.82.

Combined effects of rhBMP-2 and rhVEGF coated onto implants on osseointegration: pilot study

• Huh JB
• Yun MJ
• Jeong CM
• Shin SW
• Jeon YC

• KMID: 2045110
• DOI: http://doi.org/10.4047/jkap.2013.51.2.82

Abstract

PURPOSE
The present study is aimed to evaluate the combined effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human vascular endothelial growth factor (rhVEGF) coated onto anodized implants on osseointeration.
MATERIALS AND METHODS
Six New Zealand white rabbit were used in this study. Each animal received 4 implants that were either coated with rhBMP-2 and rhVEGF (Study group) or anodized implant (Control group) in both tibia. This was performed using a randomized split-mouth design. A total 24 implants were used. The implant stability quotient (ISQ) value using resonance frequency analyser and removal torque (RTQ) measurement were investigated at 2 and 8 weeks. The t-test was used for statistical analysis (alpha=.05).
RESULTS
Control and study group showed good osseointegration at 8 weeks. The ISQ and RTQ values of study group were significant compared with the control group at 8 weeks (P<.05). However, No statistical significance was observed at 2 weeks (P>.05).
CONCLUSION
It was concluded that rhBMP-2 with rhVEGF coated onto anodized implants can induce better osseointegration at late healing period.

Keyword

rhBMP-2; rhVEGF; Implant stability quotient; Removal torque; Osseointegration

MeSH Terms

Animals
Bone Morphogenetic Protein 2
Humans
New Zealand
Osseointegration
Pilot Projects
Tibia
Torque
Vascular Endothelial Growth Factor A
Bone Morphogenetic Protein 2
Vascular Endothelial Growth Factor A

Figure

• 

  Fig. 1. Procedures of surgery in rabbit tibia. A: marking the incision area, B: exposure of tibia, C: marking the insertion portion, D: implant insertion.

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  Fig. 2. The measurements of implant stability and removal torque. A: Osstell Mentor for implant stability quotient value, B: removal torque gauge MGT12 for removal torque measurement.

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  Fig. 3. Mean and standard deviation of ISQ values in each group.

• 

  Fig. 4. Mean and standard deviation of RTQ values in each group.

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