J Korean Assoc Oral Maxillofac Surg.  2007 Aug;33(4):359-366.

The effects of hyaluronic acid gel on the healing of oral mucosa

• Kim HJ
• Shin CH
• Hong J
• Choi JH

Abstract

PURPOSE
In spite of various advantages of hyaluronic acid in wound healing, there are few research about wound healing process and period in oral and maxillofacial surgery. So, We evaluated the effects of local application of hyaluronic acid gel on wound healing of the oral mucosa using this animal model.
MATERIALS AND METHODS
Young adult New Zealand White rabbits, weighting between 2.5 and 3.0kg, were used. Almost uniform round ulcerscould be created on the gingival of the rabbits by chemical injury with acetic acid. In experimental group, hyaluronic acid gel was applied daily until the wounds healed and in control group, ulcer lesion was not any treatment. The lengths of ulcers were measured the longest and shortest axes of the ulcers and calculated the areas of ulcer. For histological examination, specimens were made, and observed under a light microscope.
RESULTS
The results showed that the number of fibroblasts, new blood vessels and the epithelial thickness from experimental group was higher than from control group. Hyaluronic acid promoted proliferation of the fibroblast, keratinocytes isolated from gingival tissue of rabbits in vitro. Topical application of hyaluronic acid accelerated healing of ulcers created in rabbits.
CONCLUSION
The hyaluronic acid may be effective for wound healing of oral mucosal lesions.

Keyword

Hyaluronic acid; Wound healing; Oral mucosa

MeSH Terms

Acetic Acid
Blood Vessels
Fibroblasts
Humans
Hyaluronic Acid*
Keratinocytes
Models, Animal
Mouth Mucosa*
Rabbits
Surgery, Oral
Ulcer
Wound Healing
Wounds and Injuries
Young Adult
Acetic Acid
Hyaluronic Acid