Korean J Biol Psychiatry.  2014 Feb;21(1):1-13.

A Review of Brain Magnetic Resonance Imaging Correlates of Successful Cognitive Aging

• Ji EK
• Chung IW
• Youn T

Abstract

Normal aging causes changes in the brain volume, connection, function and cognition. The brain changes with increases in age and difference of gender varies at all levels. Studies about normal brain aging using various brain magnetic resonance imaging (MRI) variables such as gray and white matter structural imaging, proton spectroscopy, apparent diffusion coefficient, diffusion tensor imaging and functional MRI are reviewed. Total volume of brain increases after birth but decreases after 9 years old. During adulthood, total volume of brain is relatively stable. After 35 years old, brain shrinks gradually. The changes of gray and white matters by aging show different features. N-acetylaspartate decreases or remains unchanged but choline, creatine and myo-inositol increase with aging. Apparent diffusion coefficient decreases till 20 years old and then becomes stable during adulthood and increase after 60 years old. Diffusion tensor properties in white matter tissue are variable during aging. Resting-state functional connectivity decreases after middle age. Structural and functional brain changes with normal aging are important for studying various psychiatric diseases such as dementia, schizophrenia and bipolar disorder. Our review may be helpful for studying longitudinal changes of these diseases and successful aging.

Keyword

Successful aging; Brain magnetic resonance imaging; Cognitive function

MeSH Terms

Adult
Aging*
Bipolar Disorder
Brain*
Child
Choline
Cognition
Creatine
Dementia
Diffusion
Diffusion Tensor Imaging
Humans
Magnetic Resonance Imaging*
Middle Aged
Parturition
Protons
Schizophrenia
Spectrum Analysis
Young Adult
Choline
Creatine
Protons