J Korean Soc Radiol.
2022 May;83(3):527-537. 10.3348/jksr.2022.0038.
Brain Iron Imaging in Aging and Cognitive Disorders: MRI Approaches
- Affiliations
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- 1Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 2Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea.
- KMID: 2530071
- DOI: http://doi.org/10.3348/jksr.2022.0038
Abstract
- Iron has a vital role in the human body, including the central nervous system. Increased deposition of iron in the brain has been reported in aging and important neurodegenerative diseases. Owing to the unique magnetic resonance properties of iron, MRI has great potential for in vivo assessment of iron deposition, distribution, and non-invasive quantification. In this paper, we will review the MRI methods for iron assessment and their changes in aging and neurodegenerative diseases, focusing on Alzheimer’s disease. In addition, we will summarize the limitations of current approaches and introduce new areas and MRI methods for iron imaging that are expected in the future.
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