Korean J Clin Neurophysiol.  2014 Jun;16(1):1-7. 10.14253/kjcn.2014.16.1.1.

Application of Iron Related Magnetic Resonance Imaging in the Neurological Disorders

Affiliations
  • 1Department of Neurology, Pusan National University Yangsan HospitalResearch Institute for Convergence of Biomedical Science and Technology, Yangsan, Korea. jhlee.neuro@pusan.ac.kr

Abstract

Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is the natural process with normal aging, excessive iron accumulation is also observed in various neurological disorders such as neurodegeneration with brain iron accumulation, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Friedreich ataxia, and others. Magnetic resonance image (MRI) is a useful method for detecting iron deposits in the brain. It can be a powerful tool for diagnosis and monitoring, while furthering our understanding of the role of iron in the pathophysiology of a disease. In this review, we will introduce the mechanism of iron toxicity and the basics of several iron-related MRI techniques. Also, we will summarize the previous results concerning the clinical application of such MR imagings in various neurological disorders.

Keyword

Iron; Neurodegenerative disorders; MRI

MeSH Terms

Aging
Alzheimer Disease
Brain
Diagnosis
DNA
Friedreich Ataxia
Iron*
Magnetic Resonance Imaging*
Multiple Sclerosis
Myelin Sheath
Nervous System Diseases*
Neurodegenerative Diseases
Oxygen
Parkinson Disease
Reactive Oxygen Species
Synaptic Transmission
DNA
Iron
Oxygen
Reactive Oxygen Species
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