J Korean Neuropsychiatr Assoc.  2004 Sep;43(5):537-545.

A Study on Depression, Anxiety and Quality of Life in Amenorrhea Schizophrenics Treated with Risperidone

Affiliations
  • 1Seoul National Hospital, Seoul, Korea. 3plus7@hanmail.net
  • 2Department of Psychiatry, College of Medicine, Ewha Women's University, Seoul, Korea.
  • 3Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
  • 4Department of Preventive Medicine and Public Health, College of Medicine, Ewha Women's University, Seoul, Korea.

Abstract


OBJECTIVES
Amenorrhea, one of the most common side effects of neuroleptics, has known to be associated with prolactin elevation. Hyperprolactinemia seriously affects mental health causing depression, anxiety or hostility, while also affecting physical health causing amenorrhea, galactorrhea or sexual dysfunction. The possible correlation between risperidone-induced amenorrhea and depression, anxiety and quality of life was evaluated in a cross-sectional open study.
METHODS
During a five-month period, WHO quality of life-BREF (WHOQOL), Beck depression inventory (BDI) and Statetrait anxiety inventory (STAI) were applied twice at two-month intervals for 30 patients with risperidone-induced amenorrhea and 22 patients without amenorrhea.
RESULTS
Amenorrhea group had significantly higher scores in BDI and STAI-state, while showing lower scores in the quality of life than control group. The total BDI and STAI-state scores were more negatively correlated with WHOQOL score in amenorrhea group.
CONCLUSION
Patients with risperidone-induced amenorrhea rated themselves significantly more depressed and more anxious, and a lower quality of life compared to the control group. Clinicians should be more active in evaluating and treating hyperprolactinemic side effects such as amenorrhea, galactorrhea, depression and anxiety.

Keyword

Schizophrenia; Risperidone; Hyperprolactinemia; Depression; Anxiety; Quality of life

MeSH Terms

Amenorrhea*
Antipsychotic Agents
Anxiety*
Depression*
Female
Galactorrhea
Hostility
Humans
Hyperprolactinemia
Mental Health
Pregnancy
Prolactin
Quality of Life*
Risperidone*
Schizophrenia
Antipsychotic Agents
Prolactin
Risperidone
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