J Korean Cancer Assoc.  2001 Feb;33(1):41-48.

Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report)

Affiliations
  • 1Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
  • 2Department of Internal Medicine, Hallym University College of Medicine, Korea.
  • 3Department of Preventive Medicine, Dogguk University College of Medicine, Korea.
  • 4Institute of Environmental Medicine, Seoul National University Medical Research Center, Korea.
  • 5Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
  • 6Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Abstract

PURPOSE: The interactive effects of genetic polymorphisms of cytochrome P4502E1 (CYP2E1) & N-acetyltransferase 1 (NAT1) and smoking on lung cancer development were evaluated in hospital based case-control study.
MATERIALS AND METHODS
Male lung cancer patients (N= 157) and the male patients with no present or previous history of systemic illnesses who visited the urology department (N=138) were recruited (1998-1999). CYP2E1 & NAT1 genotypes were determined by PCR-RFLP method using RsaI and MboII digestion, respectively.
RESULTS
CYP2E1 c2 or NAT1 *10 allele did not increased the risk of lung cancer. Heavy smokers (35CONCLUSION
These results suggest the gene-environment interaction between genetic polymorphisms of CYP2E1 & NAT1 and smoking in lung cancer development.

Keyword

Lung neoplasm; Smoking; Cytochrome P450 2E1; N-acetyltransferase 1; Interaction

MeSH Terms

Alleles
Case-Control Studies
Cytochrome P-450 CYP2E1*
Cytochromes
Digestion
Gene-Environment Interaction
Genotype
Humans
Lung Neoplasms*
Lung*
Male
Polymorphism, Genetic*
Smoke*
Smoking*
Urology
Cytochrome P-450 CYP2E1
Cytochromes
Smoke
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