J Korean Cancer Assoc.
2001 Feb;33(1):41-48.
Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report)
- Affiliations
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- 1Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
- 2Department of Internal Medicine, Hallym University College of Medicine, Korea.
- 3Department of Preventive Medicine, Dogguk University College of Medicine, Korea.
- 4Institute of Environmental Medicine, Seoul National University Medical Research Center, Korea.
- 5Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
- 6Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
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PURPOSE: The interactive effects of genetic polymorphisms of cytochrome P4502E1 (CYP2E1) & N-acetyltransferase 1 (NAT1) and smoking on lung cancer development were evaluated in hospital based case-control study.
MATERIALS AND METHODS
Male lung cancer patients (N= 157) and the male patients with no present or previous history of systemic illnesses who visited the urology department (N=138) were recruited (1998-1999). CYP2E1 & NAT1 genotypes were determined by PCR-RFLP method using RsaI and MboII digestion, respectively.
RESULTS
CYP2E1 c2 or NAT1 *10 allele did not increased the risk of lung cancer. Heavy smokers (35
These results suggest the gene-environment interaction between genetic polymorphisms of CYP2E1 & NAT1 and smoking in lung cancer development.
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