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Epigenetics and Depression: An Update

Lin E, Tsai SJ

OBJECTIVE: Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, such as epigenetics...
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Circulating Tumor Cells: Liquid Biopsy for Early Detection of Cancer

Mwesige B, Yeo SG, Yoo BC

Cancer is a complex, heterogeneic, and dynamic disease involving multiple gene-environment interactions, and affecting numerous biological pathways. As such, the development of reliable and robust non-invasive platforms constitutes a vital...
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Family History, Tobacco Smoking, and Risk of Ischemic Stroke

Fan M, Lv J, Yu C, Guo Y, Bian Z, Yang S, Yang L, Chen Y, Li F, Zhai Y, Wang P, Chen J, Chen Z, Qi L, Li L, on behalf of the China Kadoorie Biobank Collaborative Group

BACKGROUND AND PURPOSE: Both genetic factors and smoking are associated with ischemic stroke (IS) risk. However, little is known about the potential interaction of these factors. We aimed to assess...
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Predicting Behavior Problems in Korean Preschoolers: Interactions of the SLC6A4 Gene and Maternal Negative Affectivity

Ha J, Jun HJ, Shin H, Chung IJ, Park E, Min SK, Kim E

OBJECTIVE: This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of SLC6A4 on behavior problems in children. METHODS: Study participants comprised 143 preschoolers and...
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Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers

Bae JM

Based on epidemiological and genomic characteristics, lung cancer in never smokers (LCNS) is a different disease from lung cancer in smokers. Based on current research, the main risk factor for...
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Evolutionary Psychiatry I-Concept of Evolutionary Psychology and Evolutionary Psychopathology

Park CJ, Kang UG

The evolutionary theory is applied to explain a multitude of natural and social phenomena. In medicine, evolutionary biology and psychology enables us to take perspectives beyond the biomedical paradigm of...
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Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology

Bae JM

The hygiene hypothesis (HH) proposed by Strachan in 1989 was expanded to explain the inverse association between the occurrence of allergy disorders and the risk of infectious diseases and parasite...
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RORA Polymorphism Interacts with Childhood Maltreatment in Determining Anxiety Sensitivity by Sex: A Preliminary Study in Healthy Young Adults

Min JA, Lee HJ, Lee SH, Park YM, Kang SG, Park YG, Chae JH

OBJECTIVE: Recent studies have reported associations of retinoid-related orphan receptor alpha (RORA) gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether...
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Effects of Soy Product Intake and Interleukin Genetic Polymorphisms on Early Gastric Cancer Risk in Korea: A Case-Control Study

Yang S, Park Y, Lee J, Choi IJ, Kim YW, Ryu KW, Sung J, Kim J

PURPOSE: The current study investigated whether the combined effects of soy intake and genetic polymorphisms of interleukin (IL) genes modify gastric cancer risk. MATERIALS AND METHODS: A total of 377 cases...
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Genetic Signatures of Asthma Exacerbation

Park HW, Tantisira

Asthma exacerbation (AE) usually denotes worsening of asthma symptoms that requires intense management to prevent further deterioration. AE has been reported to correlate with clinical and demographic factors, such as...
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Replication of Early B-cell Factor 1 (EBF1) Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population

Kim HJ, Min JY, Min KB

OBJECTIVES: Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity....
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Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors

Mandelli L, Toscano E, Porcelli S, Fabbri C, Serretti A

In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to...
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The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy

Yu J, Ahn K, Shin YH, Kim KW, Suh DI, Yu HS, Kang MJ, Lee KS, Hong SA, Choi KY, Lee E, Yang SI, Seo JH, Kim BJ, Kim HB, Lee SY, Choi SJ, Oh SY, Kwon JY, Lee KJ, Park HJ, Lee PR, Won HS, Hong SJ, COCOA study group

PURPOSE: Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to...
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Gene-Environment Interactions Should be Considered in Future Studies to Understand the Association Between Prenatal Folate Supplementation and Asthma Development

Yu J

No abstract available.
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Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects

Lee JU, Kim JD, Park CS

Over the past three decades, a large number of genetic studies have been aimed at finding genetic variants associated with the risk of asthma, applying various genetic and genomic approaches...
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Association of Dietary Vitamin D and Calcium With Genetic Polymorphisms in Colorectal Neoplasia

Park Y, Kim J

The incidence trends of colorectal cancer have varied over time, and there is wide geographical variation across the world. Regarding colorectal cancer, diverse modifiable environmental or intrinsic risk factors have...
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Interactions Between Innate Immunity Genes and Early-Life Risk Factors in Allergic Rhinitis

Seo JH, Kim HY, Jung YH, Lee E, Yang SI, Yu HS, Kim YJ, Kang MJ, Kim HJ, Park KS, Kwon JW, Kim BJ, Kim HB, Kim EJ, Lee JS, Lee SY, Hong SJ

PURPOSE: Allergic rhinitis (AR) is a common chronic disease. Many factors could affect the development of AR. We investigated early-life factors, such as delivery mode, feeding method, and use of...
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Determinants of sensitization to allergen in infants and young children

Kim HY, Shin YH, Han MY

Atopic sensitization is a complex phenomenon that changes dynamically with age throughout childhood; its prevalence increases with age in young children. Additionally, with increasing age, the prevalence of sensitization to...
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Neuroimmunological Aberrations and Cerebral Asymmetry Abnormalities in Schizophrenia: Select Perspectives on Pathogenesis

Venkatasubramanian G, Debnath M

  • KMID: 2171124
  • Clin Psychopharmacol Neurosci.
  • 2014 Apr;12(1):8-18.
Within the wide-ranging gamut of factors that comprise gene-environment interactions postulated to underlie schizophrenia, the crosstalk between environmental factors and feto-maternal immune components has been put forth as one of...
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MRAS Genetic Variation Is Associated with Atherothrombotic Stroke in the Han Chinese Population

Liu H, Huang XQ, Yang M, Ji XM, Du X, Zheng J

BACKGROUND AND PURPOSE: Atherothrombotic cerebral infarction [atherothrombotic stroke (ATS)] shares common risk factors and pathophysiological mechanisms with coronary artery disease (CAD), and both diseases appear to have common susceptibility loci....
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