Psychiatry Investig.  2016 Mar;13(2):247-249. 10.4306/pi.2016.13.2.247.

Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors

Affiliations
  • 1Department of Biomedical and Neuromotor Sciences, Institute of Psychiatry, University of Bologna, Bologna, Italy. laura.mandelli@unibo.it

Abstract

In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress.

Keyword

Schizophrenia; Age of onset; ST8SIA2; Stressful life events; Gene-environment interaction

MeSH Terms

Age of Onset*
Gene-Environment Interaction
Humans
Polymorphism, Single Nucleotide
Psychotic Disorders
Schizophrenia*
Full Text Links
  • PI
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr