- The Present and Future of Precision Medicine in Psychiatry: Focus on Clinical Psychopharmacology of Antidepressants
-
Serretti A
- KMID: 2405228
- Clin Psychopharmacol Neurosci.
- 2018 Feb;16(1):1-6.
- doi: 10.9758/cpn.2018.16.1.1
Precision medicine is a concept which is recently gaining momentum in all branches of medicine. In particular in psychiatry it is greatly needed given the huge societal costs of psychiatric... -
- CITED
-
- Close
- SHARE
-
- Close
- Pharmacogenetics and Depression: A Critical Perspective
-
Corponi F, Fabbri C, Serretti A
- KMID: 2459684
- Psychiatry Investig.
- 2019 Sep;16(9):645-653.
- doi: 10.30773/pi.2019.06.16
Depression leads the higher personal and socio-economical burden within psychiatric disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal response still poses a major challenge and is... -
- CITED
-
- Close
- SHARE
-
- Close
- Corrigendum: A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial
-
Han Cs, Wang SM, Bahk WM, Lee SJ, Patkar AA, Masand PS, Mandelli L, Pae CU, Serretti A
- KMID: 2508991
- Clin Psychopharmacol Neurosci.
- 2020 Nov;18(4):641.
- doi: 10.9758/cpn.2020.18.4.641
-
- CITED
-
- Close
- SHARE
-
- Close
- No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
-
Serretti A, Fabbri C, Pellegrini S, Porcelli S, Politi P, Bellino S, Menchetti , Mariotti V, Demi C, Martinelli V, Cappucciati M, Bozzatello P, Brignolo E, Brambilla , Pae CU, Balestrieri M, De Ronchi
- KMID: 2316266
- Psychiatry Investig.
- 2013 Jun;10(2):180-189.
OBJECTIVE: Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been... -
- CITED
-
- Close
- SHARE
-
- Close
- Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
-
Mandelli L, Toscano E, Porcelli S, Fabbri C, Serretti A
- KMID: 2316623
- Psychiatry Investig.
- 2016 Mar;13(2):247-249.
- doi: 10.4306/pi.2016.13.2.247
In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to... -
- CITED
-
- Close
- SHARE
-
- Close
- Dimensions of Delusions in Major Depression: Socio-demographic and Clinical Correlates in an Unipolar-Bipolar Sample
-
Zaninotto , Souery D, Calati R, Camardese , Janiri L, Montgomery S, Kasper S, Zohar J, De Ronchi , Mendlewicz J, Serretti A
- KMID: 2171064
- Clin Psychopharmacol Neurosci.
- 2015 Apr;13(1):48-52.
- doi: 10.9758/cpn.2015.13.1.48
OBJECTIVE: The present study aims at exploring associations between a continuous measure of distorted thought contents and a set of demographic and clinical features in a sample of unipolar/bipolar depressed... -
- CITED
-
- Close
- SHARE
-
- Close
- Clinical Utility of Fluid Biomarker in Depressive Disorder
-
Serretti A
- KMID: 2536469
- Clin Psychopharmacol Neurosci.
- 2022 Nov;20(4):585-591.
- doi: 10.9758/cpn.2022.20.4.585
Major depressive disorders are ranked as the single largest contributor to non-fatal health loss and biomarkers could largely improve our routine clinical activity by predicting disease course and guiding treatment.... -
- CITED
-
- Close
- SHARE
-
- Close
- A Practical Utility and Benefit of Pharmacogenetic-based Antidepressant Treatment Strategy for Major Depressive Disorder Patients with Difficult-to-treat
-
Lee KH, Bahk WM, Lee SJ, Serretti A, Pae CU
- KMID: 2513402
- Clin Psychopharmacol Neurosci.
- 2021 Feb;19(1):160-165.
- doi: 10.9758/cpn.2021.19.1.160
Objective: We report the results of pharmacogenomics-based antidepressant treatment (PGXt) results in treating treatment-resistant major depressive disorder (TRD) patients in real practice. Methods: Nine patients were prescribed NeuropharmagenⓇ for selection of... -
- CITED
-
- Close
- SHARE
-
- Close
- Genetics of Treatment Outcomes in Major Depressive Disorder: Present and Future
-
Fabbri C, Serretti A
- KMID: 2502121
- Clin Psychopharmacol Neurosci.
- 2020 Feb;18(1):1-9.
- doi: 10.9758/cpn.2020.18.1.1
Pharmacogenetic testing is a useful and increasingly widespread tool to assist in antidepressant prescription. More than ten antidepressants (including tricyclics, selective serotonin reuptake inhibitors and venlafaxine) have already genetic biomarkers... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of the Dysbindin Gene on Antimanic Agents in Patients with Bipolar I Disorder
-
Yun DH, Pae CU, Drago A, Mandelli L, De Ronchi , Patkar AA, Paik IH, Serretti A, Kim JJ
- KMID: 1706123
- Psychiatry Investig.
- 2008 Jun;5(2):102-105.
- doi: 10.4306/pi.2008.5.2.102
OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role... -
- CITED
-
- Close
- SHARE
-
- Close
- How to Utilize Clinical and Genetic Information for Personalized Treatment of Major Depressive Disorder: Step by Step Strategic Approach
-
Fabbri C, Serretti A
- KMID: 2508975
- Clin Psychopharmacol Neurosci.
- 2020 Nov;18(4):484-492.
- doi: 10.9758/cpn.2020.18.4.484
Depression is the single largest contributor to non-fatal health loss and affects 322 million people globally. The clinical heterogeneity of this disorder shows biological correlates and it makes the personalization... -
- CITED
-
- Close
- SHARE
-
- Close
- CRY1 Variations Impacts on the Depressive Relapse Rate in a Sample of Bipolar Patients
-
Drago A, Monti B, De Ronchi , Serretti A
- KMID: 2316397
- Psychiatry Investig.
- 2015 Jan;12(1):118-124.
- doi: 10.4306/pi.2015.12.1.118
OBJECTIVE: A relevant part of the social and personal burden caused by Bipolar Disorder (BD) is related to depressive phases. Authors investigated the genetic impact of a set of variations... -
- CITED
-
- Close
- SHARE
-
- Close
- Epistatic Interactions between CREB and CREM Variants in Affective Disorder
-
Chiesa A, Marsano A, Han C, Lee SJ, Patkar AA, Pae CU, Serretti A
- KMID: 1994612
- Psychiatry Investig.
- 2014 Apr;11(2):200-203.
- doi: 10.4306/pi.2014.11.2.200
The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents' response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and... -
- CITED
-
- Close
- SHARE
-
- Close
- Abelson Helper Integration Site-1 Gene Variants on Major Depressive Disorder and Bipolar Disorder
-
Porcelli S, Pae CU, Han C, Lee SJ, Patkar AA, Masand PS, Balzarro B, Alberti S, De Ronchi , Serretti A
- KMID: 2316377
- Psychiatry Investig.
- 2014 Oct;11(4):481-486.
- doi: 10.4306/pi.2014.11.4.481
OBJECTIVE: The present study aimed to explore whether 4 single nucleotide polymorphisms (SNPs) within the AHI1 gene could be associated with major depressive disorder (MD) and bipolar disorder (BD), and... -
- CITED
-
- Close
- SHARE
-
- Close
- Possible Modulatory Role of ARC Gene Variants in Mood Disorders
-
Crisafulli C, Calabrò M, Mandelli L, Wang SM, Lee SJ, Han C, Patkar A, Masand P, Pae CU, Souery D, Mendlewicz J, Serretti A
- KMID: 2513389
- Clin Psychopharmacol Neurosci.
- 2021 Feb;19(1):46-52.
- doi: 10.9758/cpn.2021.19.1.46
Objective: The genetic background of mood disorders is gradually emerging through the use of large multicenter samples but a detailed phenotyping is complementary in elucidating the role of modulating variants. Methods:... -
- CITED
-
- Close
- SHARE
-
- Close
- ZNF804A Gene Variants Have a Cross-diagnostic Influence on Psychosis and Treatment Improvement in Mood Disorders
-
Calabrò M, Mandelli L, Crisafulli C, Nicola MD, Colombo R, Janiri L, Lee SJ, Jun TY, Wang SM, Masand PS, Patkar AA, Han C, Pae CU, Serretti A
- KMID: 2502148
- Clin Psychopharmacol Neurosci.
- 2020 May;18(2):231-240.
- doi: 10.9758/cpn.2020.18.2.231
Objective: Genetic variations in the gene encoding zinc finger protein 804A gene (ZNF804A) have been associated with major depression and bipolar disorder. In this work we focused on the potential... -
- CITED
-
- Close
- SHARE
-
- Close
- Genes Involved in Neurodevelopment, Neuroplasticity and Major Depression: No Association for CACNA1C, CHRNA7 and MAPK1
-
Calabrò M, Mandelli L, Crisafulli C, Lee SJ, Jun TY, Wang SM, Patkar AA, Masand PS, Han C, Pae CU, Serretti A
- KMID: 2457399
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):364-368.
- doi: 10.9758/cpn.2019.17.3.364
OBJECTIVE: Genetics factors are likely to play a role in the risk, clinical presentation and treatment outcome in major depressive disorder (MDD). In this study, we investigated the role of... -
- CITED
-
- Close
- SHARE
-
- Close
- A Pharmacogenomic-based Antidepressant Treatment for Patients with Major Depressive Disorder: Results from an 8-week, Randomized, Single-blinded Clinical Trial
-
Han C, Wang SM, Bahk WM, Lee SJ, Patkar AA, Masand PS, Mandelli L, Pae CU, Serretti A
- KMID: 2428976
- Clin Psychopharmacol Neurosci.
- 2018 Nov;16(4):469-480.
- doi: 10.9758/cpn.2018.16.4.469
OBJECTIVE: Pharmacogenomic-based antidepressant treatment (PGATx) may result in more precise pharmacotherapy of major depressive disorder (MDD) with better drug therapy guidance. METHODS: An 8-week, randomized, single-blind clinical trial was conducted to... -
- CITED
-
- Close
- SHARE
-
- Close
