- A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity
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Song M, Do H, Kwon OK, Yang EJ, Bae JS, Jeong TC, Song KS, Lee S
- KMID: 2170656
- Biomol Ther.
- 2014 Mar;22(2):155-160.
Thelephoric acid is an antioxidant produced by the hydrolysis of polyozellin, which is isolated from Polyozellus multiplex. In the present study, the inhibitory effects of polyozellin and thelephoric acid on... -
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- Cytochrome P450 2E1 activity in a Korean population
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Muhn DH, Chae JM, Bahn JY, Song HJ, Kim HK, Kwon JT, Sohn DR
- KMID: 1554771
- Korean J Physiol Pharmacol.
- 1997 Oct;1(5):597-602.
Cytochrome P450 2E1 (CYP2E1) is involved in the toxicity and carcinogenicity of a number of solvents and xenobiotics. Like the various types of oxidation pharmacogenetics, the activity of the enzyme shows a discernible... -
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- Identification of Polymorphisms in CYP2E1 Gene and Association Analysis among Chronic HBV Patients
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Chun JY, Park BL, Cheong HS, Kim JY, Park TJ, Lee JS, Lee HS, Kim YJ, Shin HD
- KMID: 2166465
- Genomics Inform.
- 2009 Dec;7(4):187-194.
Cytochrome P450 2E1 (CYP2E1) is a member of the cytochrome P450 superfamily, and it is a key enzyme responsible for the metabolic activation of many smallmolecular-weight compounds such as alcohol,... -
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- The Effects of CYP2E1 and CYP2C19 Polymorphisms on the Susceptibility for Gastric Cancer
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Lee JE, Lee RA, Kim KH, Kang BY, Lee JH
- KMID: 1521596
- J Korean Surg Soc.
- 2007 Aug;73(2):114-120.
PURPOSE: The gastric cancer is a common malignancy worldwide. Developing a screening test for gastric cancer is important because early-stage gastric cancer has a good prognosis. So, we investigated the... -
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- The Association between Pneumoconiosis and Genetic Polymorphism of GSTM1, GSTT1, GSTP1, NAT2, CYP2E1 and CYP1A1
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Oh CJ, Hwang MY, Lee KJ, Lee HR, Cho BM
- KMID: 1607562
- Korean J Occup Environ Med.
- 2005 Jun;17(2):85-94.
OBJECTIVES: To investigate effects of genetic polymorphism of glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1), glutathione S-transferase P1 (GSTP1), N-acetyltransferase (NAT2), cytochrome P450 2E1 (CYP2E1) and cytochrome P450 1A1... -
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- Effects of cytochrome P450 2E1 polymorphism on hepatic injury in patients with alcoholic liver cirrhosis
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Koh MS, Lee JY, Joo MH, Jeon MJ, Noh HJ, Kim JB, Kim DJ, Kim JA, Chung YH
- KMID: 2253146
- Korean J Med.
- 2001 Mar;60(3):222-227.
BACKGROUND: There is an individual variation in the hepatic injuries following alcohol abuse, which may be partly caused by the diverse activities of enzymes participating in the degradation of alcohol.... -
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- Constitutive expression and changes of cytochrome P450 isozymes mRNAs by vehicles (petrolatum, DMSO, ethanol) in rat skin using semi-quantitative RT-PCR
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Lee AY, Lee KH, Ko DS, Chey WY
- KMID: 1607080
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):407-412.
Many drugs are primarily metabolized by the cytochrome P450s (CYPs). Drug metabolites would be important allergens for adverse drug reactions such as drug eruptions. Skin tests with a suspected drug have conducted to... -
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- Analysis of CYP2E1 and GSTM1 Polymorphisms for the Determination of Genetic Susceptibility to Korean Patients with Colon Cancer
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Lee OY, Park GT, Lee CG, Lee JY, Shim SH, Choi HS, Yoon BC, Ham JS, Lee MH, Kee CS, Park KN, Jun KY
- KMID: 1556954
- Korean J Gastroenterol.
- 1998 Nov;32(5):600-610.
BACKGROUND/AIMS: Genetic susceptibility to chemical carcinogens is one of the most important host factors in human cancers. This study was undertaken to reveal the association of the polymorphism of the... -
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- Hepatotoxicity in Rats Treated with Dimethylformamide or Toluene or Both
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Kim KW, Chung YH
- KMID: 2317834
- Toxicol Res.
- 2013 Sep;29(3):187-193.
The effects of toluene in dimethylformamide (DMF)-induced hepatotoxicity were investigated with respect to the induction of cytochrome P-450 (CYP) and the activities of related enzymes. The rats were treated intraperitoneally... -
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- Effects of Genetic Factor, Life Styles, and Diet on Urinary Hippuric Acid Excretion in Toluene Exposed Workers
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Yim HW, Park CY, Roh YM, Lee KS, Lee JM, Lee WC, Lee SH, Chung CK
- KMID: 2028119
- Korean J Occup Environ Med.
- 2000 Sep;12(3):405-420.
OBJECTIVES: The purpose was to investigate the distributions and the effects of genetic polymorphism of aldehyde dehydrogenase 2(ALDH2), cytochrome P450 1A1(CYP1A1), and cytochrome P450 2E1(CYP2E1) on the toluene metabolism. METHODS:... -
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- Genetic Polymorphism of Cytochrome P450 2E1 in Hepatocellular Carcinoma Patients in Korea
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Paik SW, Yoon JH, Hwang YJ, Jang YH, Lee HS, Kim CY
- KMID: 2084763
- Korean J Gastroenterol.
- 1997 Oct;30(4):503-512.
Background/Airns: Cytochrome P450 2E1 (CYP2EI) is the only enzyme that rnetabolizes very low doses of N-nitrosodimethylamine (NDMA) and is characterized by its ethanol inducibility. Recently, it has been shown in... -
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- The Colorectal Cancer Risk of Meat Intake, Smoking, and CYP2E1 Polymorphisms: The Comparison of Colorectal Cancer Patients with Controls
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Ahn EJ, Lee RA, Chung SS, Kim KH, Park EB
- KMID: 1844901
- J Korean Surg Soc.
- 2006 Oct;71(4):262-268.
PURPOSE: Genetic susceptibility for colorectal cancer is explained by polymorphisms of the drug-metabolizing enzymes. CYP2E1 activate the procarcinogens and they are involved in carcinogenesis. We analyzed the polymorphisms of CYP2E1... -
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- CYP1A2 polymorphism and theophylline clearance in Korean non-smoking asthmatics
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Yim EY, Kang HR, Jung JW, Sohn SW, Cho SH
- KMID: 2397300
- Asia Pac Allergy.
- 2013 Oct;3(4):231-240.
- doi: 10.5415/apallergy.2013.3.4.231
BACKGROUND: Theophylline is mainly metabolized by cytochrome P450 (CYP) 1A2 and CYP2E1 which show inter-individual variations. However, the underlying mechanism remains unknown in humans. We investigated the relationship between differences... -
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- Genetic susceptibilities of cytochrome P450 1A1, 2E1, and N-acetyltransferase 2 to the risks for Korean head and neck cancer patients
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Lee YS, Kim TG, Woo SS, Shim KS, Kong G
- KMID: 2009658
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2000 Jul;22(4):373-382.
Individual genetic susceptibilities to cancers may result from several factors including differences in xenobiotics metabolism to chemical carcinogens, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. Among... -
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- Association of Genetic Polymorphisms of Aldehyde Dehydrogenase II and CYP2E1 and Clinical Characteristics of Patients with Alcohol Dependence
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Chung IW, Kim YR, Chi KH, Kim H
- KMID: 2202795
- J Korean Soc Biol Psychiatry.
- 2002 Jul;9(1):42-49.
OBJECTIVE: This study was to explore the relation of genetic polymorphisms of ALDH2 and CYP2E1 to clinical characteristics of alcoholic patients and alcohol induced liver damage. METHODS: The genotype and allele... -
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- The Protective Effects of Garlic against Carbon tetrachloride-induced Hepatotoxicity
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Choi BS, Lee JM, Park JD, Hong YP
- KMID: 2283257
- Korean J Prev Med.
- 2002 Aug;35(3):221-228.
OBJECTIVES: The purpose of this study was to find the protective effects of garlic on the halogenated hydrocarbon induced hepatotoxicities, and the possible protection mechanisms involved. METHODS: Male Sprague-Dawley rats received... -
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- The Role of Genetic Polymorphism of Cytochrome P450 2E1 in Bladder Cancer in Korea
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Choi J, Lee S, Lee K, Choi I, Lee Y, Im H, Lee SY, Yoon K, Kim S, Park M, Choi H, Choi W, Yoo K, Cho S, Kang D
- KMID: 2303997
- Korean J Epidemiol.
- 2000 Jun;22(1):59-67.
Although the association of genetic polymorphisms in glutathione S-transferase(GST) and N-acetyltransferase(NAT) with bladder cancer has been reported, limited numbers of studies have been indicated the association of CYP2E1 with bladder... -
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- Studies for Pathogenesis of Fixed Drng Emptions Through the Change of Cytochrome p450 Isozymes
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Lee AY, Kim MJ, Lee KE, Chey WY, Choi J
- KMID: 2250974
- Korean J Dermatol.
- 2001 Nov;39(11):1246-1252.
The reasons of same site recurrence in fixed drug eruptions (FDEs) remain to be clarified. Although the nature of antigen in FDE is unknown, drug metabolites could play a role... -
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- Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer
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Lee HC, Yoon YB, Kim CY
- KMID: 1051581
- Korean J Intern Med.
- 1997 Jun;12(2):128-136.
OBJECTIVES: Metabolic activation is a prerequisite for the carcinogenic effect of many carcinogens, and considerable interindividual variation exists in the metabolic capacity to activate the carcinogens. The cytochromes P-450 (CYPs)... -
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- A Case-Control Study on Effects of Genetic Polymorphisms of GSTM1, GSTT1, CYP1A1 and CYP2E1 on Risk of Lung Cancer
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Nan HM, Kim H, Kang JW, Bae JW, Choe KH, Lee KH, Kim ST, Won CH, Kim YM
- KMID: 2282988
- Korean J Prev Med.
- 1999 Jun;32(2):123-129.
OBJECTIVES: This study was performed to investigate effects of genetic polymorphisms of glutathione S-transferase M1 (GSTM1), glutathione S-transferase M1 (GSTT1), cytochrome P450 1A1 (CYP1A1) and cytochrome P450 2E1 (CYP2E1) on... -
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