Korean J Psychopharmacol.  1998 Oct;9(2):193-196.

Risperidone-induced Hyperprolactinemia

• Chung YC
• Eun HB

Abstract

We experienced 6 cases of risperidone-induced hyperprolactinemia. Their mean age were 31.2+/- 7.1 years and 1 case was male and 5 cases were females. The reported neuroendocrine side effects were amenorrhea, galactorrhea and gynecomastia. The prolactin levels checked at the reported time of side effects or early stage of drug trial were more than 10 fold of normal level (male : 7.3-16.1 ng/ml, female 7.8-19.6 ng/ml). In male patient with the side effect of gynecomastia, we reduced the dose of risperidone from 6 to 3mg/day which eliminated the symptom 3 month later. As far female patients, risperidone was replaced with the equivalent doses of thioridazine or haloperidol except one female patient to whom risperione was stopped and benzodiazepine was only given. Follow-up results of them were : 1) one female patient was dropped out and 2) the others were all recovered from their neuroendocrine side effects after 3-4 months later.

Keyword

Risperidone; Hyperprolactinemia

MeSH Terms

Amenorrhea
Benzodiazepines
Female
Follow-Up Studies
Galactorrhea
Gynecomastia
Haloperidol
Humans
Hyperprolactinemia*
Male
Pregnancy
Prolactin
Risperidone
Thioridazine
Benzodiazepines
Haloperidol
Prolactin
Risperidone
Thioridazine