- Effectiveness of Switching to Long-acting Injectable Aripiprazole in Patients with Recent-onset and Chronic Schizophrenia
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Kim SW, Lee BJ, Cheon EJ, Won SH, Jo A, Kim JM, Chung YC
- KMID: 2539650
- Clin Psychopharmacol Neurosci.
- 2023 Feb;21(1):57-67.
- doi: 10.9758/cpn.2023.21.1.57
Objective: This study investigated the effectiveness of switching to once-monthly long-acting injectable (LAI) aripiprazole from other second-generation antipsychotics including LAI paliperidone palmitate in both recent-onset and chronic schizophrenia patients. Methods: This... -
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- Methylome-wide Association Study of Patients with Recent-onset Psychosis
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Piao YH, Cui Y, Rami FZ, Li L, Karamikheirabad M, Kang SH, Kim SW, Kim JJ, Lee BJ, Chung YC
- KMID: 2532808
- Clin Psychopharmacol Neurosci.
- 2022 Aug;20(3):462-473.
- doi: 10.9758/cpn.2022.20.3.462
Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns... -
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- Risperidone Induced DNA Methylation Changes in Dopamine Receptor and Stathmin Genes in Mice Exposed to Social Defeat Stress
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Rami FZ, Nguyen TB, Oh YE, Karamikheirabad M, Le TH, Chung YC
- KMID: 2530472
- Clin Psychopharmacol Neurosci.
- 2022 May;20(2):373-388.
- doi: 10.9758/cpn.2022.20.2.373
Objective: Understanding complex epigenetic mechanisms is necessary to fully elucidate the effects of antipsychotic drug. This study investigated DNA methylation and mRNA expression levels of dopamine D2 and D1 receptor... -
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- Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatum in vivo
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Hong AR, Jang JG, Chung YC, Won SY, Jin BK
- KMID: 2526965
- Exp Neurobiol.
- 2022 Feb;31(1):42-53.
- doi: 10.5607/en21032
To explore the potential function of interleukin-13 (IL-13), lipopolysaccharide (LPS) or PBS as a control was unilaterally microinjected into striatum of rat brain. Seven days after LPS injection, there was... -
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- Impact of Social Defeat Stress on DNA Methylation in Drd2, Nr3c1, and Stmn1 in Wild-type and Stmn1 Knock-out Mice
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Oh YE, Nguyen TB, Rami FZ, Karamikheirabad M, Chung YC
- KMID: 2526847
- Clin Psychopharmacol Neurosci.
- 2022 Feb;20(1):51-60.
- doi: 10.9758/cpn.2022.20.1.51
Objective: Epigenetic profiles can be modified by stress. Dopamine receptor D2 (Drd2), glucocorticoid receptor gene (Nr3c1) and Stathmin 1 (Stmn1) genes are all implicated in adaptation to stress. The aim... -
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- A Comparison of Speech Features between Mild Cognitive Impairment and Healthy Aging Groups
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Kim KW, Na SH, Chung YC, Shin BS
- KMID: 2522278
- Dement Neurocogn Disord.
- 2021 Oct;20(4):52-61.
- doi: 10.12779/dnd.2021.20.4.52
Background and Purpose: Language dysfunction is a symptom common to patients with Alzheimer's disease (AD). Speech feature analysis may be a patient-friendly screening test for early-stage AD. We aimed to... -
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- Dynamics of T Lymphocyte between the Periphery and the Brain from the Acute to the Chronic Phase Following Ischemic Stroke in Mice
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Kim M, Kim SD, Kim KI, Jeon EH, Kim MG, Lim YR, Lkhagva-Yondon E, Oh Y, Na K, Chung YC, Jin BK, Song YS, Jeon MS
- KMID: 2515814
- Exp Neurobiol.
- 2021 Apr;30(2):155-169.
- doi: 10.5607/en20062
Stroke causes systemic immunosuppression. T lymphocytes are involved in infarct size in the early stages of stroke. However, the phenotypes of T lymphocytes and their functions in peripheral immune organs... -
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- Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia
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Shen J, Shen G, Kim WS, Tsogt U, Liu C, Sui J, Chung YC
- KMID: 2515113
- Psychiatry Investig.
- 2021 Apr;18(4):284-294.
- doi: 10.30773/pi.2020.0335
Objective The present study investigated the functional neuroanatomy underlying negative and positive schemas towards the self and others in patients with early stage schizophrenia spectrum disorders (SSDs) using a task-based... -
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- Network Structures of Social Functioning Domains in Schizophrenia and Bipolar Disorder: A Preliminary Study
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Ryu S, Lee H, Lee DK, Nam HJ, Chung YC, Kim SW
- KMID: 2508981
- Clin Psychopharmacol Neurosci.
- 2020 Nov;18(4):571-579.
- doi: 10.9758/cpn.2020.18.4.571
Objective: This study used network analyses to examine network structures reflecting interactions between specific domains of social functioning in schizophrenia (SZ) and bipolar disorder (BD). Methods: We used the World Health... -
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- Differences in Symptoms, Functions, and Their Outcomes According to the Degree of Trauma in Patients with Early Psychosis
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Moon S, Yoon JA, Lee KY, Piao YH, Kim SW, Lee BJ, Lee SH, Kim JJ, Won S, Kim SH, Kang SH, Kim E, Chung YC, Yu JC
- KMID: 2506212
- J Korean Neuropsychiatr Assoc.
- 2020 Aug;59(3):228-235.
- doi: 10.4306/jknpa.2020.59.3.228
Objectives There has been growing interest in the relationship between mental illness and premorbid trauma recently. The purpose of this study was to examine the difference in symptoms, functions,... -
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- Korean Medication Algorithm for Schizophrenia 2019, Second Revision: Treatment of Psychotic Symptoms
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Lee JS, Yun JY, Kang SH, Lee SJ, Choi JH, Nam B, Lee SH, Chung YC, Kim CH
- KMID: 2505656
- Clin Psychopharmacol Neurosci.
- 2020 Aug;18(3):386-394.
- doi: 10.9758/cpn.2020.18.3.386
Objective: In 2001, the Korean College of Neuropsychopharmacology and the Korean Society for Schizophrenia Research developed the Korean Medication Algorithm Project for Schizophrenia (KMAP-SPR 2001, revised 2006) through a consensus... -
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- Validation of the Korean Version of the 15-Item CommunityAssessment of Psychic Experiences in a College Population
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Kim SW, Kim JK, Han JH, Jhon M, Kim JW, Lee JY, Kim JM, Na HJ, Kang YS, Chung YC, Yoon JS
- KMID: 2500236
- Psychiatry Investig.
- 2020 Apr;17(4):306-311.
- doi: 10.30773/pi.2019.0215
Objective To investigate the reliability and validity of the Korean version of the Community Assessment of Psychic Experiences-15 item positive scale (CAPE-15) in college students. Methods This study had two stages: initial... -
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- Defining Treatment Response, Remission, Relapse, and Recovery in First-Episode Psychosis: A Survey among Korean Experts
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Lee BJ, Kim SW, Kim JJ, Yu JC, Lee KY, Won SH, Lee SH, Kim SH, Kang SH, Kim E, Kim K, Piao YH, Chung YC
- KMID: 2501492
- Psychiatry Investig.
- 2020 Feb;17(2):163-174.
- doi: 10.30773/pi.2019.0240
Objective For the proper treatment of first-episode psychosis, assessment of treatment response, remission, relapse, and recovery is important. Therefore, the present study aimed to develop operational definitions of clinical outcomes... -
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- Korean Treatment Guideline on Pharmacotherapy of Co-existing Symptoms and Antipsychotics-related Side Effects in Patients with Schizophrenia
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Yun JY, Lee JS, Kang SH, Nam B, Lee SJ, Lee SH, Choi J, Kim CH, Chung YC
- KMID: 2462049
- Korean J Schizophr Res.
- 2019 Oct;22(2):21-33.
- doi: 10.16946/kjsr.2019.22.2.21
OBJECTIVES: The current study covers a secondary revision of the guidelines for the pharmacotherapy of schizophrenia issued by the Korean Medication Algorithm for Schizophrenia (KMAP-SCZ) 2001, specifically for co-existing symptoms... -
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- The Development of the Brooding Scale
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Kim JH, Piao Y, Kim WS, Park JJ, Kang NI, Lee KH, Chung YC
- KMID: 2451939
- Psychiatry Investig.
- 2019 Jun;16(6):443-449.
- doi: 10.30773/pi.2019.04.16
OBJECTIVE: The purpose of this study was to develop a Brooding Scale (BS) and to confirm its psychometric properties. METHODS: A preliminary questionnaire was developed based on a literature review and... -
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- Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPPâº-lesioned Rats via Ciliary Neurotrophic Factor
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Kim KI, Baek JY, Jeong JY, Nam JH, Park ES, Bok E, Shin WH, Chung YC, Jin BK
- KMID: 2450220
- Exp Neurobiol.
- 2019 Apr;28(2):289-299.
- doi: 10.5607/en.2019.28.2.289
Transient receptor potential vanilloid subtype 1 (TRPV1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (DA) neurons in MPPâº-lesioned rats via ciliary neurotrophic factor (CNTF). The present study determined whether... -
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- Alteration of Semantic Networks during Swear Words Processing in Schizophrenia
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Lee SW, Jeong B, Park JI, Chung GH, Lee HJ, Cui Y, Kim WS, Oh KH, Oh IS, Shen GF, Chung YC
- KMID: 2441634
- Clin Psychopharmacol Neurosci.
- 2019 Feb;17(1):64-73.
- doi: 10.9758/cpn.2019.17.1.64
OBJECTIVE: Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in... -
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- Comparative Efficacy and Safety of Long-acting Injectable and Oral Second-generation Antipsychotics for the Treatment of Schizophrenia: A Systematic Review and Meta-analysis
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Park SC, Choi MY, Choi J, Park E, Tchoe HJ, Suh JK, Kim YH, Won SH, Chung YC, Bae KY, Lee SK, Park CM, Lee SH
- KMID: 2428965
- Clin Psychopharmacol Neurosci.
- 2018 Nov;16(4):361-375.
- doi: 10.9758/cpn.2018.16.4.361
We aimed to compare the efficacy and safety of long-acting injectable (LAI) and oral second-generation antipsychotics (SGAs) in treating schizophrenia by performing a systematic review and meta-analysis. MEDLINE, EMBASE, PsycINFO,... -
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- Pharmacotherapeutic Strategies to Prevent Relapse in Schizophrenia
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Kim J, Piao Y, Shen Q, Chung YC
- KMID: 2429226
- J Korean Neuropsychiatr Assoc.
- 2018 Aug;57(3):225-229.
- doi: 10.4306/jknpa.2018.57.3.225
Successful treatment is very high in patients with first episode schizophrenia (FES). On the other hand, the problem is a frequent relapse often caused by non-compliance. The non-compliance rate in... -
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- Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (¹â¸F)
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Kim JH, Son YD, Kim JH, Lee HJ, Kang NI, Chung GH, Park JI, Cui Y, Kim WS, Chung YC
- KMID: 2419987
- Clin Psychopharmacol Neurosci.
- 2018 Aug;16(3):324-332.
- doi: 10.9758/cpn.2018.16.3.324
OBJECTIVE: Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia. METHODS: We recruited... -
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