Korean J Med.  2005 Jul;69(1):96-100.

A case of primary biliary cirrhosis associated with autoimmune primary hypothyroidism

• Kwon SK
• Yang SY

Abstract

Primary biliary cirrhosis (PBC) is an idiopathic chronic non-suppurative destructive inflammation of intrahepatic bile ducts and rare in Korea. Although its pathogenesis is not fully understood, immunologic dysregulation is suspected because of presence of antimitochondrial antibody (AMA) and association with other autoimmune disease, such as autoimmune thyroid disease. Evidence of hypothyroidism in PBC is relatively common in western countries, however it has not been reported in Korea. And it is uncertain whether the reason is ethnic factor or unawareness of the disease. Recently, we experienced a 50-year-old women with hypothyroidism who had elevated alkaline phosphatase and gamma glutamyl transpeptidase. This is the first case of hypothyroidism associated with PBC in Korea.

Keyword

Primary biliary cirrhosis; Hypothyroidism

MeSH Terms

Alkaline Phosphatase
Autoimmune Diseases
Bile Ducts, Intrahepatic
Female
gamma-Glutamyltransferase
Humans
Hypothyroidism*
Inflammation
Korea
Liver Cirrhosis, Biliary*
Middle Aged
Thyroid Diseases
Alkaline Phosphatase
gamma-Glutamyltransferase