Korean J Gynecol Oncol Colposc.  2002 Dec;13(4):336-341.

Expression of C-MYC, C-RAS, C-ERB B-2 Oncogenes and P53 Gene in Hydatidiform Mole

• Choi HS
• Kim SM
• Park CS

Abstract

OBJECTIVE
To date early predictors for the development of persistent gestational trophoblastic disease (PGTD) after evacuation of a complete hydatidiform mole were not known. The purpose of this study was to investigate whether there is a correlation between oncogene expression and PGTD after evacuation of molar pregnancy.
METHODS
The expression of c-myc, c-ras, c-erb B-2 oncogene and p53 gene product in paraffin-embedded trophoblastic tissues using immunohistochemical staining were investigated retrospectively. We compared 20 cases of PGTD group with 20 cases of spontaneous regression group after molar evacuation.
RESULTS
Expression of p53 gene was in 25% of regression group while it was detected in 15% of PGTD group. The c-myc, c-ras, c-erb B-2 oncogene product was detected in 80%, 20%, 40% of regression group while it was detected in 75%, 15%, 65% of PGTD group respectively.
CONCLUSION
This result showed that correlation between c-myc, c-ras, c-erb B-2 and p53 gene product expression and PGTD is not significant.

Keyword

c-myc; c-ras; c-erb B-2; p53; Hydatidiform mole

MeSH Terms

Female
Genes, p53*
Gestational Trophoblastic Disease
Hydatidiform Mole*
Molar
Oncogene Proteins
Oncogenes*
Pregnancy
Retrospective Studies
Trophoblasts
Oncogene Proteins