Ewha Med J.  1979 Dec;2(4):201-204. 10.12771/emj.1979.2.4.201.

Effect of Estrous Cycle and Preimplantation on Hepatic Microsomal Cytochrome P-450 Levels in Mice

• Ham YA
• Kim SR
• Hong YS
• Sung NE

• KMID: 1969657
• DOI: http://doi.org/10.12771/emj.1979.2.4.201

Abstract

Cytochrome P-450 is sometimes called the microsomal carbon monoxide-binding pigment. It is present in the microsomal fraction of several animal tissues, and also in the mitochondrial fraction of adrenal cortex, but not in the mitochondria of other tissues. Cytochrome P-450, the liver microsomal drugmetabolizing enzyme is membranebound and fraction as multicomponent electron transport system for the metabolism of a variety of endogenous substrates(such as steroids, fatty acids, and bile acids) and exogenous substance (such as drugs, carcinogens, insecticides, and many other foreign compounds). The effect estrous cycle and preimplantation on the levels of hepatic microsomal cytochrome P-450 in mice were determined. In effect of estrous cycle on microsomal cytochrome P-450 level, the most increment was at estrus. The content of cytochrome P-450 was increased significantly at pregnant Day 3 of preimplantation.

MeSH Terms

Adrenal Cortex
Animals
Bile
Carbon
Carcinogens
Cytochrome P-450 Enzyme System*
Cytochromes*
Electron Transport
Estrous Cycle*
Estrus
Fatty Acids
Female
Insecticides
Liver
Metabolism
Mice*
Mitochondria
Steroids
Carbon
Carcinogens
Cytochrome P-450 Enzyme System
Cytochromes
Fatty Acids
Insecticides
Steroids