Ewha Med J.  1987 Jun;10(2):107-111. 10.12771/emj.1987.10.2.107.

The Effect of H1 and H2 Blockade on Cutaneous Histamine Response in Man

• Myung KB

• KMID: 1965719
• DOI: http://doi.org/10.12771/emj.1987.10.2.107

Abstract

Histamine-induced cutaneous wheal responses were measured in 24 healthy subjects. The effect of the potent H1 blocker, hydroxyzine HCI, the H2 blocker, cimetidine, and the two drugs in combination was determined. The H1 blocker alone produced a mean wheal suppression of 77%(p<0.005). The H2 blocker alone produced a mean wheal suppression of 35%(p<0.01). The H1 plus H2 blocker produced 79% suppression. But the augmented suppression of H1 plus H2 blocker vs H1 blocker was not statistically significant (p>0.05). The result provide evidence that H2 receptors are present in the human cutaneous blood vessel, but additional studies must be performed to determine the significance of combined H1 and H2 blockade over H1 blocker alone in suppression of histamine-induced wheal formation.

MeSH Terms

Blood Vessels
Cimetidine
Histamine*
Humans
Hydroxyzine
Receptors, Histamine H2
Cimetidine
Histamine
Hydroxyzine
Receptors, Histamine H2