Yonsei Med J.  1996 Apr;37(2):97-103. 10.3349/ymj.1996.37.2.97.

The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice

• Ulugol A
• Karadag H
• Dokmeci D
• Dokmeci I

• KMID: 2069425
• DOI: http://doi.org/10.3349/ymj.1996.37.2.97

Abstract

Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.

Keyword

Compound 48/80; histamine; hypoxia; body temperature; histamine receptors

MeSH Terms

Animal
Anoxia/*drug therapy/physiopathology
Body Temperature/*drug effects
Convulsions/prevention & control
Male
Mice
Mice, Inbred BALB C
Receptors, Histamine H1/*physiology
Receptors, Histamine H2/*physiology
p-Methoxy-N-methylphenethylamine/*pharmacology