J Korean Assoc Maxillofac Plast Reconstr Surg.  2005 Jul;27(4):307-314.

Expression of osseointegration-related genes around titanium implant: BMP2, BMP4

  • 1Department of Oral and Maxillofacial surgery, Seoul National University Bundang Hospital, Korea.
  • 2Division of Oral and Maxillofacial Surgery, Department of Dentistry, St. Vincent's Hospital, The Catholic University of Korea, Korea. omsjyj@kornet.net


After dental implant are planted into their bony site among the various growth factors associated with bone formation. BMP is expressed in the bone surrounding the implant fixture. By taking a close look at BMP2, BMP4 which are growth factors that take put in bone formation, its histologic features and radiographic bone healing patterns we would like to examine the mechanism of osseointegration. We randomly used 8 male and female house rabbit amd used diameter 5 mm height spiral shaped implants(Ostem, Korea) for animal use handled as a resorbable blast machined(RBM) surface and machined surface. 2group were formed and each group had RBM surface and machined surface implant or a simple bone cavity. After 3, 7, 14 and 28 days post surgery 2 objects were sacrificed from each group and histologic specimens were acquired. RT-PCR analysis was conducted and after HandE staining the extent of osseointegration was measured applying a histologic feature and histomorphometric analysis program. Quanitity one -4.41(Bio-Rad, USA) was used after scanning the PCR product image of the growth factors manifested in each group. According to the histomorphometric features the RBM, Machined surface group showed increased contact between bone and implant surface at 3, 7, 14 and 28 days after surgery. The BMP2 level increased in both experiment groups but remained unchanged in the contrast group. BMP4 levels stayed steady after the early post implantation period for RBM but showed decreased in the machined surface group and contrast group. The amount of contact between bone and implant surface increased with the passage of time. BMP2, BMP4 were expressed in both experimental group and contrast group. These growth factors play a role in osseointegration of implant.


Osseointegration; Titanium implant; BMP2; BMP4; Histomorphometric analysis; RT-PCR analysis

MeSH Terms

Dental Implants
Intercellular Signaling Peptides and Proteins
Polymerase Chain Reaction
Dental Implants
Intercellular Signaling Peptides and Proteins
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