The effect of purified human BMP with DLB(hBMP-I) on osseointegration of immediate titanium implants: cases report

Lee, Eun Young

Abstract

Osseointegration implies a direct structural and functional connection between living bone and the surface of a load-carrying implant. Although titanium possesses good osteoconduction ability, it does not seem to have osteoinductive capabilities. Because present knowledge of the relationship between BMP and bone regeneration arises mainly from studies of induced bone formation in heterotopic sites, it would be helpful to determine whether BMP plays any part in the process of osseointegration. The purpose of this observation was to evaluate the effect of purified human BMP coating DLB(hBMP-I) in immediate implant surgery to obtain the functional structure of implant asap. The most significant observation of the these cases was that hBMP-I with the immediate implant stimulated earlier close direct new bone formation. The finding indicate that hBMP-I may stimulate proliferation and differentiation of mesenchymal cells and improve the effect of initial stability and early loading in the immediate implant sites.