Korean J Anesthesiol.  2005 Nov;49(5):612-616. 10.4097/kjae.2005.49.5.612.

Effects of EDTA (Ethylene Diamine Tetra Acetic Acid) in Propofol on Serum Electrolyte, BUN and Creatinine during Long Time Neurosurgical Operation

• Lee JS
• Kim JH
• Kim BI

• KMID: 1936814
• DOI: http://doi.org/10.4097/kjae.2005.49.5.612

Abstract

BACKGROUND: EDTA was added to the formulation of propofol to inhibit microbial growth due to accidental extrinsic contamination. This study was conducted to determine whether the EDTA in the propofol would affect the ionized calcium homeostasis, other electrolyte balance, blood urea nitrogen (BUN) and creatinine (Cr) in long time craniotomy patients.
METHODS
Forty two patients undergoing surgery for clipping of a cerebral aneurysm were randomly assigned to receive either propofol without EDTA (propofol group; n = 20), or propofol with EDTA (propofol EDTA group; n = 22). The ionized calcium, total calcium, total magnesium, phosphate, potassium, sodium, BUN and Cr in the blood were measured at before anesthetic induction, 4 hours after induction and 1 hour after the operation.
RESULTS
There were no significant differences in the ionized calcium, other electrolytes, BUN and Cr between the two groups. CONCLUSIONS: The addition of EDTA into propofol appears to have no significant effects on the electrolyte balance, BUN and Cr concentration.

Keyword

BUN; calcium; craniotomy; creatinine; ethylene diaminetetraacetic acid; propofol

MeSH Terms

Blood Urea Nitrogen
Calcium
Characidae*
Craniotomy
Creatinine*
Edetic Acid*
Electrolytes
Homeostasis
Humans
Intracranial Aneurysm
Magnesium
Potassium
Propofol*
Sodium
Water-Electrolyte Balance
Calcium
Creatinine
Edetic Acid
Electrolytes
Magnesium
Potassium
Propofol
Sodium