Korean J Clin Pathol.
1998 Mar;18(1):46-50.
A Case of EDTA Dependent Platelet Phagocytosis by Neutrophils in Mycosis Fungoides
- Affiliations
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- 1Department of Clinical Pathology, College of Medicine, Dongguk University, Kyong Ju, Korea.
- 2Department of Pathology, College of Medicine, Dongguk University, Kyong Ju, Korea.
- 3Department of Dermatology, College of Medicine, Dongguk University, Kyong Ju, Korea.
- 4Department of Clinical Pathology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- In vitro ethylene-diamine-tetra-acetic acid (EDTA) dependent satellitism and phagocytosis of platelets by neutrophils have been considered to be rare phenomena. It is associated with pseudothrombocytopenia, abnormal histogram of platelets and pseudoleukocytosis on complete blood cell count (CBC) by automated blood cell counter, but these findings are not found in heparinized or sodium citrated blood. It has no clinical significance such as bleeding tendency or abnormal platelet function. EDTA dependent platelet satellitosis and phagocytosis must be differentiated from true thrombocytopenia. We report a case of EDTA dependent platelet phagocytosis by neutrophils in a 68 year-old male patient who was diagnosed as mycosis fungoides. His EDTA blood smear showed frequent phagocytosis of platelets by neutrophils and occasional platelet satellitism. The bood cell counts were within normal limits without pseudothrombocytopenia. Phagocytized platelets were confirmed by immunohistochemistry using GpIIb/IIIa antibody and transmission electron micrographs.
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