Korean J Anesthesiol.  2003 Nov;45(5):583-588. 10.4097/kjae.2003.45.5.583.

Hemodynamic Stability during the Induction of Anesthesia with Propofol Plus Fentanyl, Ketamine and Fentanyl-Ketamine

• Yoon CS
• Park SC
• Park PS
• Kwon YE
• Lee JH
• Kim DC

• KMID: 1935945
• DOI: http://doi.org/10.4097/kjae.2003.45.5.583

Abstract

BACKGROUND: This study was conducted to investigate hemodynamic stability during anesthesia induction and tracheal intubation, using propofol plus fentanyl, propofol plus ketamine, and propofol plus fentanyl and ketamine.
METHODS
Sixty adult patients were randomly allocated to one of three groups according to the agents used for induction: propofol (2 mg/kg) plus fentanyl (2 mcg/kg) (PF), propofol (2 mg/kg) plus ketamine (0.1 mg/kg) (PK), propofol (2 mg/kg) plus fentanyl (2 mcg/kg) and ketamine (0.1 mg/kg) (PFK). Hemodynamic responses were assessed by measuring changes in mean arterial pressure (MAP), heart rate (HR), and rate-pressure product (RPP).
RESULTS
MAP, HR and RPP changes during the induction of anesthesia tended to be greater in the PK group than in the PF and PFK groups. After the injection of propofol, MAP, HR, and RPP fell significantly below baseline values in the all groups, but remained relatively stable in the PK groups. After tracheal intubation, MAP, HR and RPP increased significantly compared with the pre-intubation values in the all groups, but reached a level significantly above baseline only in the PK group.
CONCLUSIONS
A combination of propofol plus fentanyl and ketamine reduces fluctuations in the hemodynamic variables associated with the induction of anesthesia and tracheal intubation than combinations of propofol plus fentanyl or propofol plus ketamine.

Keyword

fentanyl; hemodynamics; induction; ketamine; propofol

MeSH Terms

Adult
Anesthesia*
Arterial Pressure
Fentanyl*
Heart Rate
Hemodynamics*
Humans
Intubation
Ketamine*
Propofol*
Fentanyl
Ketamine
Propofol