Korean J Anesthesiol.  1991 Apr;24(2):316-323. 10.4097/kjae.1991.24.2.316.

Effects of Adenosine Triphosphate Triphosphate on Hemodynamics and Intrapulmonary Shunting in Ethrane - N2O Anesthetized Man

• Yoon MH
• Yoo KY
• Ha IH

• KMID: 1933598
• DOI: http://doi.org/10.4097/kjae.1991.24.2.316

Abstract

In order to evaluate the efficacy of adenosine triphosphate (ATP) in the reduction of left ventricular afterload, we studied the hemodynamic and intrapulmonary shunt effects of intravenous ATP during ethrane-N2O anesthesia. Hemodynamic measurements and arterial and mixed venous blood gas analyses were made in ten patients before (baseline) and 10 min after. ATP infusion at 80,60,120 and 250 mcg/kg/min, respective. The results were as follows: 1) ATP produced a rapid and stable reduction in mean arterial pressure resulting from a marked decrease in systemic vascular resistance. 2) Cardiac index increased significantly by 14, 47 and 72% from baseline value after intravenous infusion of ATP at rates of 60, 120 and 250 mcg/kg/min, respectively. 3) Stroke volume index, heart rate, mean pulmonary arterial pressure, pulmonary capillary wedge pressure and central venous pressure increased significantly, whereas systemic vasular resistance and pulmonary vascular resistance decreased significantly in a dose related fashion during ATP infusion. 4) Intrapulmonary ehunt fraction increased from 5.67% to 6.73, 8.28, 9.85 and 13.38% after intra- venous infusion of ATP at rates of 30, 60, 120 and 250 mcg/kg/min, respectively. 5) Arterial oxygen tension decreased significantly after ATP infusion. These results suggest that ATP might be of value in augmentation of cardiac performance in patients with low cardiac output with high peripheral vascular resistance.

Keyword

Anesthetic Techniques; hypotensive; adenosine triphosphate; Lung; shunting

MeSH Terms

Adenosine Triphosphate*
Adenosine*
Anesthesia
Arterial Pressure
Blood Gas Analysis
Cardiac Output, Low
Central Venous Pressure
Enflurane*
Heart Rate
Hemodynamics*
Humans
Infusions, Intravenous
Lung
Oxygen
Pulmonary Wedge Pressure
Stroke Volume
Vascular Resistance
Adenosine
Adenosine Triphosphate
Enflurane
Oxygen