Korean Circ J.  1998 Jun;28(6):863-870. 10.4070/kcj.1998.28.6.863.

Assessment of Coronary Flow Reserve with Adenosine Triphosphate Compared to the Response to Adenosine

• Kim W
• Takh SJ
• Kim HS
• Shin JH
• Cho YK
• Choi OK
• Lim KS
• Choi B

• KMID: 2228884
• DOI: http://doi.org/10.4070/kcj.1998.28.6.863

Abstract

BACKGROUND
Previous studies have indicated adenosine triphosphate (ATP) is as potent coronary vasodillator as adenosine (A). We designed this study to compare the vasomotion of coronary artery (CA) between the infusion of ATP and that of A (1).
METHOD AND RESULTS
Ten patients with normal CA (6 male and 4 female) age ranging from 41 to 74 years (57+/-11) were studied at LAD and RCA for measurement of coronary flow reserve (CFR), time to maximum effect (Tmax), time to baseline (TBL) in CA during ATP and A infusion. Tmax was achieved earlier with ATP than A, and these results suggest that maximum vasodilation occurs faster with ATP. Side effect profile was similar in 2 patients with mild chest pain with ATP and A.
CONCLUSION
Since it has appeared that vasodilatory effect of ATP was comparable to A which has been used in pharmacological stress test in many diagnostic modalities, ATP can be used safely in many clinical setting where A has been used.

Keyword

ATP (adenosine triphosphate); Adenosine; CFR (coronary flow reserve)

MeSH Terms

Adenosine Triphosphate*
Adenosine*
Chest Pain
Coronary Vessels
Exercise Test
Humans
Male
Vasodilation
Adenosine
Adenosine Triphosphate