Korean J Anesthesiol.  1986 Feb;19(1):84-88.

Prevention and Management in a Patient with Family History of Malignant Hyperthermia

• Koh SS
• Kim JS
• Lee KN
• Moon JI
• Lee CH

Abstract

Malignant hyperthermia is defined as a potentially fatal hypermetabolic syndrome characterized by hyperpyrexia, skeletal muscle rigidity, tachycardia, respiratory and metabolic acidosis, cyanosis etx. There is no simple noninvasive test to identify the susceptible individuals. A history of hyperpyrexia and/or muscle rigidity during previous general or a family history of such a condition provides the anesthesiologist with valuable information. Avoidance of potent inhalational anesthetic agents and other triggering agenta, and the selective use of regional anesthesia with either a local anesthetic agent or neuroleptic anesthesia, are the usual acceptable guidelines in the anesthetic management of susceptible individuals. Dentrolene sodium has been shown to be effective in the prevention and treatment of malignant hyperthermia in malignant hyperthermia susceptible swine. We gave Dantrolene sodium orally as a part of the prophylaxia for malignant hyperthermia in a 34yearts-old woman who underwent an emergency bilateral salpingectomy and who had a family history of malignant hyperthermia. We report on this patient with a family history of hyperthermia and reviewed the literature concerning malignant hyperthermia.

MeSH Terms

Acidosis
Anesthesia
Anesthesia, Conduction
Anesthetics
Cyanosis
Dantrolene
Emergencies
Female
Fever
Humans
Malignant Hyperthermia*
Muscle Rigidity
Muscle, Skeletal
Salpingectomy
Sodium
Swine
Tachycardia
Anesthetics
Dantrolene
Sodium