Korean J Pediatr Hematol Oncol.  2002 Oct;9(2):239-244.

Anti-cardiolipin Antibody and Coagulopathy in a Patient with Kawasaki Disease Complicated by Meningitis

Affiliations
  • 1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea. mk6309@ajou.ac.kr

Abstract

Antiphospholipid antibodies are a family of autoantibodies directed against certain phospholipids or phospholipid-binding proteins. Antiphospholipid antibody syndrome can occur as a secondary event to an underlying autoimmune disease, most commonly systemic lupus erythematosus and also occur in certain infectious diseases and drug reactions. We experienced a patient with Kawasaki disease who had anticardiolipin antibodies accompanied by coagulation abnormalities. A 4-month-old female patient was admitted due to fever, irritability, lymph node swelling on the right submandibular area and maculopapular skin rashes on trunk and both extremities. She had prolonged activated partial thromboplastin time (aPTT). Further investigations revealed a positive anticardiolipin antibody detected by ELISA. She had right lateral sinus thrombosis on parieto-occipital area on brain MRI and thrombotic microangiopathy, resulting in necrosis of toe. She showed considerable improvement in affected skin after dexamethasone treatment for 3 weeks. Thrombosis was resolved completely 2 months later.

Keyword

Anti-cardiolipin antibody; Kawasaki disease; Coagulopathy

MeSH Terms

Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Autoantibodies
Autoimmune Diseases
Brain
Communicable Diseases
Dexamethasone
Enzyme-Linked Immunosorbent Assay
Exanthema
Extremities
Female
Fever
Humans
Infant
Lateral Sinus Thrombosis
Lupus Erythematosus, Systemic
Lymph Nodes
Magnetic Resonance Imaging
Meningitis*
Mucocutaneous Lymph Node Syndrome*
Necrosis
Partial Thromboplastin Time
Phospholipids
Skin
Thrombosis
Thrombotic Microangiopathies
Toes
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Autoantibodies
Dexamethasone
Phospholipids
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