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Coagulation abnormalities and bleeding in pregnancy: an anesthesiologist's perspective

Yoon HJ

During pregnancy, the procoagulant activity increases (manifested by elevation in factor VII, factor VIII, factor X, and fibrinogen levels), while the anticoagulant activity decreases (characterized by reduction in fibrinolysis and...
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Comparative analysis of unperforated and perforated appendicitis in laboratory values of patients who visited emergency center

Cho D, Seo JY

OBJECTIVE: Unperforated and perforated acute appendicitis need to be differentiated because appendicitis with a free perforation requires an emergency operation to prevent contamination inside the bowel from spreading into the...
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Clinical Phenotype of a First Unprovoked Acute Pulmonary Embolism Associated with Antiphospholipid Antibody Syndrome

Na YS, Jang S, Hong S, Oh YM, Lee SD, Lee JS

BACKGROUND: Antiphospholipid antibody syndrome (APS), an important cause of acquired thrombophilia, is diagnosed when vascular thrombosis or pregnancy morbidity occurs with persistently positive antiphospholipid antibodies (aPL). APS is a risk...
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Risk Factors of Delayed Intracranial Hemorrhage Following Ventriculoperitoneal Shunt

Jang SY, Kim CH, Cheong JH, Kim JM

OBJECTIVE: Placement of a ventriculoperitoneal (VP) shunt is a common neurosurgical procedure for cerebrospinal fluid diversion. A rare complication is delayed intracranial hemorrhage (ICH) secondary to VP shunting, and only...
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Consensus Guides on Stroke Thrombolysis for Anticoagulated Patients from Japan: Application to Other Populations

Toyoda K, Yamagami H, Koga M

Development of direct oral anticoagulants and their antidotes has led to the need to reconsider the eligibility of acute stroke patients who have been taking oral anticoagulants for intravenous thrombolysis....
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Non-Vitamin K Oral Anticoagulants Associated Bleeding and Its Antidotes

Steiner T, Köhrmann , Schellinger PD, Tsivgoulis G

Oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) accounts for nearly 20% of all ICH. The number of patients with an indication for oral anticoagulant therapy (OAT) increases with increasing age. OAT became...
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The Influence of Antiplatelet Drug Medication on Spine Surgery

Shin WS, Ahn DK, Lee JS, Yoo IS, Lee HY

BACKGROUND: The incidence of cardiovascular and neurovascular diseases has been increasing with the aging of the population, and antiplatelet drugs (APDs) are more frequently used than in the past. With...
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A Case of Hemophilia B Diagnosed after Rhinosinus Surgery in 37 Year-Old Patient

Kim HD, Choi IS

Hemophilia is an X-linked recessive disorder, which is classified into hemophilia A, defined by factor VIII deficiency and hemophilia B, defined by factor IX deficiency. The usual clinical presentation is...
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Analysis of the Importance of Sacroiliac Joint Fractures as a Prognostic Factor of the Patients with Pelvic Fractures

Ju YU, Cho JM, Kim NR, Lee KB, Kim JK, Oh JK

PURPOSE: The diagnosis of pelvic fractures pattern has become to be essential in the decision making of treatment modality and reducing morbidity and mortality in multiple trauma patients. Sacroiliac joint...
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Validation of Nafamostat Mesilate as an Anticoagulant in Extracorporeal Membrane Oxygenation: A Large-Animal Experiment

Han SJ, Han W, Song HJ, Kim CS, Jeong SM, Kang MW

BACKGROUND: Unfractionated heparin is commonly used for anticoagulation in extracorporeal membrane oxygenation (ECMO). Several studies have shown that nafamostat mesilate (NM) has comparable clinical outcomes to unfractionated heparin. This study...
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Performance Evaluation and Local International Sensitivity Index Verification Using Automated Coagulation Analyzer Coapresta 2000

Ham JY, Suh JS

BACKGROUND: The Coapresta 2000 (CP2000; Seikisui, Japan) system is a fully-automated random-access multiparameter coagulation analyzer equipped with a photo-optical clot detection unit. It can perform clotting time assays as well...
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Safety and Efficacy of Catheter Direct Thrombolysis in Management of Acute Iliofemoral Deep Vein Thrombosis: A Systematic Review

Elbasty A, Metcalf J

PURPOSE: Catheter direct thrombolysis (CDT) has been shown to be an effective treatment for deep venous thrombosis. The objective of the review is to improve safety and efficacy of the...
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Postoperative Spinal Epidural Hematoma: The Danger Caused by the Misuse of Thrombin-Containing Local Hemostatics

Ahn DK, Shin WS, Kim GW, Koo KH

STUDY DESIGN: Retrospective case-control study. PURPOSE: To examine the hypothesis that the misuse of thrombin-containing local hemostatics (TCLH) increases the risk of postoperative spinal epidural hematoma (POSEH). OVERVIEW OF LITERATURE: Many studies...
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Acquired Hemophilia A Combined with Systemic Lupus Erythematosus: A Case Report and Literature Review

You J, Kim H, Park JS, Chang MH, Lee CH

Acquired hemophilia A (AHA) is a rare hemorrhagic disorder caused by autoantibodies against factor VIII (FVIII). An 80-year-old woman presented multiple bruises on her upper and lower extremities, along with...
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A Case of Acquired Factor V Deficiency after Percutaneous Coronary Intervention

Yu ES, Kim DS, Choi CW

Acquired factor V deficiency is extremely rare. Here we report the case of an 88-year-old female patient who presented with hematochezia 1 month after undergoing percutaneous coronary intervention. Her laboratory...
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Treatment Option for High Grade Spleen Injury and Predictive Factors for Non-operative Management

Na JW, Lee JN, Yu BC, Lee MA, Park JJ, Lee GJ

PURPOSE: The prognostic factors of non-operative management (NOM) in high-grade spleen injuries have been extensively studied, but factors that would help treatment decisions are lacking. We compared the characteristics of...
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Safety of Surgical Tracheostomy during Extracorporeal Membrane Oxygenation

Yeo HJ, Yoon SH, Lee SE, Jeon D, Kim YS, Cho WH, Kim D

BACKGROUND: The risk of bleeding during extracorporeal membrane oxygenation (ECMO) is a potential deterrent in performing tracheostomy at many centers. To evaluate the safety of surgical tracheostomy (ST) in critically...
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Critical Value Report: Survey and Literature Review

Song JK, Ahn HJ, Kim YA

BACKGROUND: Communication with clinicians in the pre- and post-analytical period to report correct and adequate laboratory test results is crucial. Specifically, the notification of critical values that identify a treatable...
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The Results of Proximal Femoral Nail for Intertrochanteric Fracture in Hemodialysis Patient

Song KS, Yoon SP, Lee SK, Lee SH, Yang BS, Park BM, Yang IH, Lee BS, Yeom JU

PURPOSE: Hip fractures in hemodialysis patients are accompanied by high rates of complications and morbidities. Previous studies have mainly reported on nonunion and avascular necrosis of femoral neck fractures in...
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The Significance of Clinical Examination for Brain Lesion Differentiation of Patients with Head Trauma after Alcohol Intoxication

Jung YH, Jeong DK, Lee JW, Moon HJ, Choi JH, Song JH

PURPOSE: There are many patients visited to ED in an alcohol intoxicated state. For these patients, it is difficult to predict by only clinical examination whether he/she would have brain...
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