J Korean Neurosurg Soc.  1989 Jan;18(1):143-147.

Intracerebral Hemorrhage in Newborn Infants Secondary to Vitamin K Deficiency

• Jung S
• Kim SH
• Kang SS

Abstract

Intracerebral hemorrhage secondary to vitamin K deficiency is presented in three newborn infants: 4 days, 28 days and 21 days of age respectively. After the administration of vitamin K(5-10 mg) either intravenously or intramusculary, prolonged prothrombin time(PT) and partial thromboplastin time(PTT) were corrected promptly. Vitamin K dependent coagulation factor deficiency due to vitamin K deficiency is accounted for the pathogenesis of hemorrhage. The possible causes of vitamin K deficiency, diagnostic methods and treatment of this disease entity are reviewed. Neurosurgeons as well as pediatricians should remain alert for the development of intracerebral hemorrhage caused by vitamin K deficiency in neonatal period.

Keyword

Coagulation factor; Intracerebral hemorrhage; Prothrombin time; Partial thromboplastin time; Vitamin K deficiency

MeSH Terms

Blood Coagulation Factors
Cerebral Hemorrhage*
Hemorrhage
Humans
Infant, Newborn*
Partial Thromboplastin Time
Prothrombin
Prothrombin Time
Thromboplastin
Vitamin K Deficiency*
Vitamin K*
Vitamins*
Blood Coagulation Factors
Prothrombin
Thromboplastin
Vitamin K
Vitamins