Korean J Physiol Pharmacol.
1999 Feb;3(1):69-74.
Systemic injection of lidocaine induce expression of c-fos mRNA and protein in adult rat brain
- Affiliations
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- 1Department of Dental Pharmacology, Wonkwang University School of Dentistry, Iksan, Chonbuk, 570-749 South Korea.
- 2Department of Biochemistry, Kyunghee University School of Medicine, Seoul 130-702, South Korea.
- 3Department of Pharmacology, Ajou University School of Medicine, Suwon, Kyungkido 442-749, South Korea.
Abstract
- Both direct and indirect environmental stress to brain were increase the expression of transcription factor c-fos in various populations of neurons. In this study, we examined whether the intraperitoneal injections of lidocaine at doses inducing convulsion within 10 min increased the level of c-fos mRNA and protein in forebrain areas. In situ hybridization using (35S)UTP-labeled antisense c-fos, cRNA increased c-fos mRNA levels though hippocampal formation, piriform cortex, septum, caudate-putamen, neostriatum, and amygdala within 2 hr. In parallel with the mRNA expression, c-FOS protein immunoreactivity was also observed in the same forebrain areas. In contrast to the seizure activity and widespread neuronal degeneration following a kainate treatment, injections of lidocaine did not produce neuronal death within 3 days. The present study indicates that lidocaine induces convulsion and c-fos expression without causing neuro-toxicity.
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