A Study of PTH, Urinary and Serum Calcium Level in Uroloithiasis Patients

Lee, Choong Hyun; Chai, Soo Eung

Abstract

During the past decade, there has been an expanding research activity in the largely neglected problem of urolithiasis, and considerable progress has been made concerning physicochemical and physiologic basis for stone formation, development of improved diagnostic criteria, and formation of new regimen for treatment. Calcium is the principal constituent of most kidney stones and hypercalciuria is the most common metabolic abnormality found in patients with nephrolithiasis. Our understanding of these disorders and others that promote the formation of renal calculi is depend on a clear appreciation, of calcium homeostasis in humans. Since the hormone that primarily influence calcium homeostasis is parathyroid hormone, the investigation is undertaken to evaluate the changing of PTH, urinary and serum calcium levels in 104 urolithiasis patients, who has been admitted to Dept. of Urology Kyung Hee University Hospital, during the period of 2 years from March, 1981 to February, 1983. The following results were obtained: 1. Among the 104 patients, male was 76 cases and female was 28 cases, and the proportion of male to female was 2.7:1. The most common age group was 4th and 5th decade. 2. In urolithiasis patients, the range of serum calcium was 8.2-12.8 mg/dl (av.9.7+/-0.7 mg/dl). Hypercalcemia (10.1 mg/dl) was found in 23 cases, and hypercalcemia with elevated PTH level was found in 3 cases. 3. In urolithiasis patients, the range of urine calcium was 30-445mg/day (av.142+/-77mg/day). Hypercalciuria (200 mg/day) was found in 19 cases, and hypercalciuria with elevated PTH level was found in 6 cases. 4. Hypercalcemia with hypercalciuria was found in 6 cases. 5. Hypercalcemia with hypercalciuria and elevated PTH level was found in only 1 case.