J Korean Soc Pediatr Nephrol.  2007 Apr;11(1):92-99.

A Case of Posterior Reversible Encephalopathy Syndrome during Cyclosporine Therapy in a Child with Steroid Resistant Nephrotic Syndrome

• Jeong MH
• Lee JH
• Yum MS
• Ko TS
• Park YS

Abstract

The posterior reversible encephalopathy syndrome(PRES) is characterized clinically by a combination of acute or subacute confusion, lethargy, visual disturbance, and seizures. PRES has been described in various clinical settings, including severe hypertension, chemotherapy, eclampsia, and seizure. We report a case of a 7-year-old girl who had taken cyclosporine for steroid resistant nephrotic syndrome. Twenty one days after the cyclosporine therapy, she was admitted due to generalized tonic clonic seizure and headache. Her blood pressure was 170/90 mmHg. Magnetic resonance(MR) imaging showed necrotic/cystic lesions involving the bilateral parieto-occipital region. After discontinuation of cyclosporine, and control of blood pressure, she had no more seizure and headache. The follow-up MR examination which was performed 6 months later showed the decreased extent of the lesion.

Keyword

Steroid resistant nephrotic syndrome; Posterior reversible encephalopathy syndrome; Cyclosporine

MeSH Terms

Blood Pressure
Child*
Cyclosporine*
Drug Therapy
Eclampsia
Female
Follow-Up Studies
Headache
Humans
Hypertension
Lethargy
Nephrotic Syndrome*
Posterior Leukoencephalopathy Syndrome*
Pregnancy
Seizures
Cyclosporine