J Korean Soc Pediatr Nephrol.
2005 Oct;9(2):245-250.
A Case of Reversible Posterior Leukoencephalopathy Syndrome during Methylprednisolone Pulse and Cyclophosphamide Therapy in a Child with Nephrotic Syndrome
- Affiliations
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- 1Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea. kkkjhd@yumc.yonsei.ac.kr
- 2Department of Diagnostic Radiology, Yonsei University, College of Medicine, Seoul, Korea.
- 3The Institute of Kidney Disease, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
- The syndrome of reversible posterior leukoencephalopathy syndrome(RPLS) is characterized clinically by acute neurologic signs such as headache, vomiting, confusion, seizures, and visual abnormalities. Radiologically, abnormalities consistent with reversible white matter edema in the occipital and parietal lobes are characteristic. RPLS has often been associated with various systemic disorders, such as hypertensive encephalopathy, eclampsia, and the use of intravenous or intrathecal immunosuppressive drugs. We report a case of RPLS that occurred after intravenous steroid pulse therapy and treatment with oral cyclophosphamide in a child with nephrotic syndrome, and we emphasize the importance of early recognition of RPLS in the treatment of nephrotic syndrome and appropriate management to prevent permanent neurologic disability.
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