Korean J Anesthesiol.  2005 Dec;49(6):S26-S34. 10.4097/kjae.2005.49.6.S26.

Effects of Gabexate Mesilate (Foy(R)) on Endotoxin-Induced Acute Lung Injury in Rabbit

• Kwak SH
• Jung G
• Choi CH
• Kim CM
• Bae HB
• Chung ST
• Jeong CY

• KMID: 1894344
• DOI: http://doi.org/10.4097/kjae.2005.49.6.S26

Abstract

BACKGROUND: This study was to clarify the effects of gabexate mesilate (Foy(R)), a synthetic protease inhibitor, on endotoxin induced acute lung injury in rabbit.
METHODS
Animals were randomly assigned to one of four groups: saline only (n = 7), saline and Escherichia coli endotoxin 5 mg/kg over 30 mins (n = 7), Foy(R) 1 mg/kg bolus, followed by infusion of Foy(R) at 1 mg/kg/h and endotoxin (n = 7), Foy(R) 2 mg/kg bolus, followed by infusion of Foy(R) at 2 mg/kg/h and endotoxin (n = 7). Infusion of saline or Foy(R) was started 0.5 hour before the start of infusion of saline or endotoxin and continued for 6.5 hours. At the end infusion animals were sacrificed, and the wet to dry (W/D) weight ratio of lung, lung injury score and leukocyte counts, percentage of polymorphonuclear leukocyte (PMNL), and concentrations of albumin and interleukin-8 (IL-8) in bronchoalveolar lavage fluid (BALF) were evaluated.
RESULTS
Endotoxin decreased the PaO2 and peripheral blood leukocyte and platelet counts. And it increased the W/D weight ratio of lung, lung injury score and leukocyte counts, percentage of PMNL, and concentrations of albumin and IL-8 in BALF. Foy(R) attenuated all these changes except the decreased peripheral blood leukocyte count.
CONCLUSIONS
These findings suggest that Foy(R) attenuates endotoxin-induced acute lung injury in rabbit by inhibiting neutrophil, IL-8 and platelet responses which may play a central role in sepsis related lung injury.

Keyword

acute lung injury; endotoxin; gabexate mesilate; rabbit

MeSH Terms

Acute Lung Injury*
Animals
Blood Platelets
Bronchoalveolar Lavage Fluid
Escherichia coli
Gabexate*
Interleukin-8
Leukocyte Count
Leukocytes
Lung
Lung Injury
Neutrophils
Platelet Count
Protease Inhibitors
Sepsis
Gabexate
Interleukin-8
Protease Inhibitors