Korean J Vet Res.  2013 Sep;53(3):169-174.

Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney

• Park IJ
• Cha SY
• Kang M
• So YS
• Bahng JY
• Jang HK

Abstract

We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and CCl4-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-alpha) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-alpha in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.

Keyword

CCl4-induced acute liver failure; cisplatin-induced acute renal failure; mineral aqueous solution; silicon

MeSH Terms

Acute Kidney Injury
Alanine Transaminase
Animals
Aspartate Aminotransferases
Blood Urea Nitrogen
Contracts
Creatine
Cytokines
Interleukin-6
Kidney*
Liver Failure, Acute
Liver*
Mice*
Mortality
Silicon
Tumor Necrosis Factor-alpha
Alanine Transaminase
Aspartate Aminotransferases
Creatine
Cytokines
Interleukin-6
Silicon
Tumor Necrosis Factor-alpha