Anesth Pain Med.  2013 Oct;8(4):226-230.

Comparison of postoperative renal and hepatic function between desflurane-remifentanil and propofol-remifentanil for nephrectomy

• Lee WY
• Yoon HS
• Lee WH
• Yoon SH
• Park SI
• Kim BM

Abstract

BACKGROUND
Choice of anesthetics in patients with a history of nephrectomy is very important for anesthesiologists. It is important for the anesthesiologist to preserve the ipsilateral kidney function and minimize deleterious effects. This study was performed to compare anesthetic agents on postoperative renal and hepatic function in patients who underwent nephrectomy.
METHODS
From 2008 to 2012, 116 patients who underwent nephrectomy in our hospital were evaluated through a retrospective study. Anesthesia was maintained with desflurane-remifentanil in the desflurane group (Group D), and propofol-remifentanil, using a target controlled infusion pump (Group T). In order to evaluate postoperative renal and hepatic function, blood urea nitrogen (BUN), serum creatinine (Cr), estimated glomerular filtration rate (eGFR), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) was measured preoperatively, postoperative day 1, 3 and 7.
RESULTS
When compared to preoperative measures, Cr and BUN levels were elevated on postoperative day 1, 3 and 7 while eGFR was decreased in both groups. There was no significant difference between the two groups. AST and ALT were also mildly elevated on postoperative day 1, 3 and 7 in both groups. There was also no significant difference between the two groups.
CONCLUSIONS
Anesthesia with desflurane-remifentanil or propofol-remifentanil alter postoperative renal and hepatic function with no significant difference between groups. Both desflurane and propofol may be chosen for general anesthesia undergoing nephrectomy patients.

Keyword

Desflurane; Nephrectomy; Total intravenous anesthesia

MeSH Terms

Alanine Transaminase
Anesthesia
Anesthesia, General
Anesthetics
Aspartate Aminotransferases
Blood Urea Nitrogen
Creatinine
Glomerular Filtration Rate
Humans
Infusion Pumps
Isoflurane
Kidney
Nephrectomy*
Propofol
Retrospective Studies
Alanine Transaminase
Anesthetics
Aspartate Aminotransferases
Creatinine
Isoflurane
Propofol